STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (410 aa)    
Predicted Functional Partners:
bioD
Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
 
 0.999
bioA
Adenosylmethionine--8-amino-7-oxononanoate transaminase; Catalyzes an intermediate step in the biosynthesis of biotin, the transamination of 7-keto-8-aminopelargonic acid (7-KAP) to form 7,8- diaminopelargonic acid (DAPA): S-adenosyl-L-methionine + 8-amino-7-oxononanoate <=> S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
  
 0.999
bioF
8-amino-7-oxononanoate synthase; Catalyzes an intermediate step in the biosynthesis of biotin, the addition of 6-carboxy-hexanoyl-CoA (pimeloyl-coA) to alanine to form 8-amino-7-oxononanoate: 6-carboxyhexanoyl-CoA + L-alanine <=> 8-amino-7-oxononanoate + CoA + CO(2).
  
 0.972
birA
biotin-(acetyl-CoA carboxylase) ligase; Acts both as a biotin-operon repressor and as the enzyme that synthesizes the corepressor, acetyl-CoA:carbon-dioxide ligase. This protein also activates biotin to form biotinyl-5-adenylate and transfers the biotin moiety to biotin-accepting proteins.
  
 
 0.964
AARI_25900
Putative aminotransferase; Identified by match to protein family PF00202: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
  
 0.896
AARI_09490
Putative cytochrome P450.
  
  
 0.834
kbl
Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.
 
  
 0.739
argD
Acetylornithine transaminase; Catalyses the following reaction: N(2)-acetyl-L-ornithine + 2-oxoglutarate <=> N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. Involved in arginine biosynthesis; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
  
 0.664
nadE
NAD(+) synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family.
      
 0.561
nadA
Quinolinate synthetase A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
 
  
 0.557
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.