node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARI_10780 | dapB | AARI_10780 | AARI_10770 | Identified by match to PF07719. The tetratrico peptide repeat (TPR) is a structural motif present in a wide range of proteins. It mediates protein-protein interactions and the assembly of multiprotein complexes. TPR motifs have been identified in various different organisms, ranging from bacteria to humans. Proteins containing TPRs are involved in a variety of biological processes, such as cell cycle regulation, transcriptional control, mitochondrial and peroxisomal protein transport, neurogenesis and protein folding. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.856 |
AARI_16100 | asd | AARI_16100 | AARI_23880 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | 0.959 |
AARI_16100 | ask | AARI_16100 | AARI_03120 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | Aspartate kinase; Catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine; Belongs to the aspartokinase family. | 0.577 |
AARI_16100 | dapA | AARI_16100 | AARI_10800 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.953 |
AARI_16100 | dapB | AARI_16100 | AARI_10770 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.969 |
AARI_16100 | dapD | AARI_16100 | AARI_21740 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | 0.496 |
AARI_16100 | dapE | AARI_16100 | AARI_21730 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | Succinyl-diaminopimelate desuccinylase; Catalyzes the fifth step in the biosynthesis of lysine from aspartate semialdehyde: the hydrolysis of succinyl-diaminopimelate to diaminopimelate and succinate. | 0.401 |
AARI_16100 | dapF | AARI_16100 | AARI_11050 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.494 |
AARI_16100 | lysA | AARI_16100 | AARI_12580 | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.540 |
asd | AARI_16100 | AARI_23880 | AARI_16100 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | 0.959 |
asd | ask | AARI_23880 | AARI_03120 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Aspartate kinase; Catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine; Belongs to the aspartokinase family. | 0.998 |
asd | dapA | AARI_23880 | AARI_10800 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.959 |
asd | dapB | AARI_23880 | AARI_10770 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. | 0.857 |
asd | dapC | AARI_23880 | AARI_21770 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Succinyldiaminopimelate transaminase; Catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis. | 0.467 |
asd | dapD | AARI_23880 | AARI_21740 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. | 0.761 |
asd | dapE | AARI_23880 | AARI_21730 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Succinyl-diaminopimelate desuccinylase; Catalyzes the fifth step in the biosynthesis of lysine from aspartate semialdehyde: the hydrolysis of succinyl-diaminopimelate to diaminopimelate and succinate. | 0.420 |
asd | dapF | AARI_23880 | AARI_11050 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.854 |
asd | lysA | AARI_23880 | AARI_12580 | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. | 0.777 |
ask | AARI_16100 | AARI_03120 | AARI_16100 | Aspartate kinase; Catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine; Belongs to the aspartokinase family. | Putative dihydrodipicolinate synthase family protein; This family comprises several pyruvate-dependent class I aldolases that use the same catalytic step to catalyze different reactions in different pathways and includes such proteins as N-acetylneuraminate lyase, MosA protein, 5-keto-4-deoxy-glucarate dehydratase, trans-o-hydroxybenzylidenepyruvate hydratase-aldolase, trans-2-carboxybenzalpyruvate hydratase-aldolase, and 2-keto-3-deoxy- gluconate aldolase. The family is also referred to as the N-acetylneuraminate lyase family; Belongs to the DapA family. | 0.577 |
ask | asd | AARI_03120 | AARI_23880 | Aspartate kinase; Catalyzes the phosphorylation of aspartate. The product of this reaction can then be used in the biosynthesis of lysine or in the pathway leading to homoserine, which participates in the biosynthesis of threonine, isoleucine and methionine; Belongs to the aspartokinase family. | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADP-dependent reductive dephosphorylation of L-aspartyl phosphate to L-aspartate-semialdehyde. Second step in the common biosynthetic pathway leading from aspartate to diaminopimelate and lysine, to methionine, and to threonine. | 0.998 |