STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (310 aa)    
Predicted Functional Partners:
thrA
Homoserine dehydrogenase; Catalyzes NAD-dependent reduction of aspartate 4-semialdehyde into homoserine. This reaction is the third step in a pathway leading from aspartate to homoserine. The latter participates in the biosynthesis of threonine and then isoleucine as well as in that of methionine.
 
 0.999
thrC
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
 
 
 0.998
purM
Phosphoribosylformylglycinamidine cyclo-ligase; Catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis.
 
    
 0.904
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Final step in methionine synthesis.
   
 
 0.869
sdaA
Catalyzes the dehydratation of L-serine into ammonia and pyruvate; Belongs to the iron-sulfur dependent L-serine dehydratase family.
  
 
 0.844
ilvE
Branched-chain-amino-acid transaminase; Last step in the biosynthesis of the branched-chain amino acids L-isoleucine, L-valine and L-leucine.
  
 
 0.838
lysA
Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.
 
  
 0.837
metB
Cystathionine gamma-synthase; Catalyzes the conversion of cysteine and succinyl-homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms.
  
 
 0.830
metB-2
Cystathionine gamma-synthase; Catalyzes the conversion of cysteine and succinyl-homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms.
  
 
 0.830
metB-3
Cystathionine gamma-synthase; Catalyzes the conversion of cysteine and succinyl-homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms.
  
 
 0.830
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
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