STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AARI_13480Putative cysteine desulfurase; Identified by match to protein family PIRSF005572: cysteine desulfurase, NifS type. Cysteine desulfurase catalyses the following reaction: L-cysteine + [enzyme]-cysteine <=> L-alanine + [enzyme]-S-sulfanylcysteine. It is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) and functions by mobilizing sulfur. (380 aa)    
Predicted Functional Partners:
moeB
Involved in the biosynthesis of a demolybdo cofactor (molybdopterin), necessary for molybdoenzymes. Plays a role in the activation of the small subunit of the molybdopterin converting factor (MoaD).
   
 0.977
thiF
Adenylyltransferase ThiF; Catalyzes the adenylation by ATP of the carboxyl-terminal glycine of ThiS, as part of the biosynthesis pathway of thiamin pyrophosphate (vitamin B1).
   
 0.977
sufU
SUF system FeS assembly protein; Identified by match to protein family TIGR01994. The SUF system is an iron-sulfur cluster assembly system that operates under iron starvation and oxidative stress. SufU may act as a scaffold on which the Fe-S cluster is built and from which it is transferred.
  
 0.976
AARI_21150
Putative cysteine desulfurase; Identified by match to protein family PIRSF005572: cysteine desulfurase, NifS type. Cysteine desulfurase catalyses the following reaction: L-cysteine + [enzyme]-cysteine <=> L-alanine + [enzyme]-S-sulfanylcysteine. It is involved in the biosynthesis of iron-sulfur clusters, thio-nucleosides in tRNA, thiamine, biotin, lipoate and pyranopterin (molybdopterin) and functions by mobilizing sulfur.
  
  
 
0.920
AARI_12440
Thiosulfate sulfurtransferase-like protein.
  
 0.915
AARI_19740
Thiosulfate sulfurtransferase-like protein.
  
 0.915
nadA
Quinolinate synthetase A subunit; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.
 
  
 0.884
nadC
Nicotinate-nucleotide diphosphorylase (carboxylating); Involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid with 5-phosphoribosyl-1-pyrophosphate in the presence of Mg2+ to produce nicotinic acid mononucleotide, pyrophosphate and carbon dioxide; Belongs to the NadC/ModD family.
  
  
 0.877
AARI_18610
MOSC domain-containing protein; Match to PF03473. The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.
  
 0.863
nadB
L-aspartate oxidase; Quinolinate synthetase B subunit. Quinolinate synthetase complex (A and B subunits) is involved in the de novo biosynthetic pathway of pyridine nucleotide formation. It catalyses the formation of quinolinic acid.
  
  
 0.837
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.