node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARI_17900 | AARI_24020 | AARI_17900 | AARI_24020 | Identified by match to PF00291: pyridoxal-phosphate dependent enzyme. | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | 0.847 |
AARI_17900 | cysE | AARI_17900 | AARI_15620 | Identified by match to PF00291: pyridoxal-phosphate dependent enzyme. | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | 0.967 |
AARI_17900 | cysK | AARI_17900 | AARI_15630 | Identified by match to PF00291: pyridoxal-phosphate dependent enzyme. | Cysteine synthase; Responsible for the formation of cysteine from O-acetyl-serine and hydrogen sulfide with the concomitant release of acetic acid; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.923 |
AARI_17900 | metB | AARI_17900 | AARI_05210 | Identified by match to PF00291: pyridoxal-phosphate dependent enzyme. | Cystathionine gamma-synthase; Catalyzes the conversion of cysteine and succinyl-homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms. | 0.958 |
AARI_24020 | AARI_17900 | AARI_24020 | AARI_17900 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Identified by match to PF00291: pyridoxal-phosphate dependent enzyme. | 0.847 |
AARI_24020 | cysE | AARI_24020 | AARI_15620 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | 0.959 |
AARI_24020 | cysK | AARI_24020 | AARI_15630 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Cysteine synthase; Responsible for the formation of cysteine from O-acetyl-serine and hydrogen sulfide with the concomitant release of acetic acid; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.818 |
AARI_24020 | cysS | AARI_24020 | AARI_05310 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | cysteine--tRNA ligase; Activates cysteine and transfers it to tRNA(Cys) as the first step in protein biosynthesis; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.834 |
AARI_24020 | cysS-2 | AARI_24020 | AARI_16310 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | cysteine--tRNA ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.602 |
AARI_24020 | glyA | AARI_24020 | AARI_26190 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
AARI_24020 | glyA-2 | AARI_24020 | AARI_27210 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
AARI_24020 | ilvA | AARI_24020 | AARI_07480 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Catalyzes the conversion of threonine into 2-oxobutanoate. Involved in isoleucine biosynthesis. The enzyme from a number of sources also acts on L-serine. | 0.928 |
AARI_24020 | metB | AARI_24020 | AARI_05210 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Cystathionine gamma-synthase; Catalyzes the conversion of cysteine and succinyl-homoserine into cystathionine and succinate. Several other reactions may also be catalysed in some organisms. | 0.972 |
AARI_24020 | sdaA | AARI_24020 | AARI_26180 | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | Catalyzes the dehydratation of L-serine into ammonia and pyruvate; Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.908 |
cysE | AARI_17900 | AARI_15620 | AARI_17900 | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | Identified by match to PF00291: pyridoxal-phosphate dependent enzyme. | 0.967 |
cysE | AARI_24020 | AARI_15620 | AARI_24020 | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | Catalyses the synthesis of L-cystathionine from L-serine and L-homocysteine. | 0.959 |
cysE | cysK | AARI_15620 | AARI_15630 | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | Cysteine synthase; Responsible for the formation of cysteine from O-acetyl-serine and hydrogen sulfide with the concomitant release of acetic acid; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.998 |
cysE | cysS | AARI_15620 | AARI_05310 | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | cysteine--tRNA ligase; Activates cysteine and transfers it to tRNA(Cys) as the first step in protein biosynthesis; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.904 |
cysE | cysS-2 | AARI_15620 | AARI_16310 | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | cysteine--tRNA ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.865 |
cysE | glyA | AARI_15620 | AARI_26190 | Serine O-acetyltransferase; Catalyses the first step of the synthesis of L-cysteine from L-serine. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.825 |