node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARI_09810 | AARI_17750 | AARI_09810 | AARI_17750 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | 0.598 |
AARI_09810 | gcvH | AARI_09810 | AARI_26200 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.622 |
AARI_09810 | lipA | AARI_09810 | AARI_20320 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.537 |
AARI_09810 | lipB | AARI_09810 | AARI_20310 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.556 |
AARI_09810 | lpdA | AARI_09810 | AARI_08260 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | E3 component of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.976 |
AARI_09810 | lpdA-2 | AARI_09810 | AARI_10940 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | E3 component of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.904 |
AARI_09810 | lpdA-3 | AARI_09810 | AARI_20270 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | E3 component of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.996 |
AARI_09810 | lplA | AARI_09810 | AARI_16020 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | Putative lipoate--protein ligase; Catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein). | 0.598 |
AARI_09810 | prs | AARI_09810 | AARI_07970 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.743 |
AARI_09810 | sucA | AARI_09810 | AARI_12350 | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61 (Dihydrolipoyllysine-residue succinyltransferase), which also binds multiple copies of EC 1.8.1.4 (Dihydrolipoyl dehydrogenase). Involved in the TCA cycle. | 0.931 |
AARI_17750 | AARI_09810 | AARI_17750 | AARI_09810 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). | 0.598 |
AARI_17750 | gcvH | AARI_17750 | AARI_26200 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.908 |
AARI_17750 | lipA | AARI_17750 | AARI_20320 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.919 |
AARI_17750 | lipB | AARI_17750 | AARI_20310 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.917 |
AARI_17750 | lpdA | AARI_17750 | AARI_08260 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | E3 component of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.567 |
AARI_17750 | lpdA-2 | AARI_17750 | AARI_10940 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | E3 component of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.567 |
AARI_17750 | lpdA-3 | AARI_17750 | AARI_20270 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | E3 component of pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes. | 0.567 |
AARI_17750 | lplA | AARI_17750 | AARI_16020 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Putative lipoate--protein ligase; Catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue in lipoate dependent enzymes. Lipoylation is essential for the function of several key enzymes involved in oxidative metabolism, including pyruvate dehydrogenase (E(2) domain), 2-oxoglutarate dehydrogenase (E(2) domain), the branched-chain 2-oxoacid dehydrogenases and the glycine cleavage system (H protein). | 0.900 |
AARI_17750 | prs | AARI_17750 | AARI_07970 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. | 0.639 |
AARI_17750 | sucA | AARI_17750 | AARI_12350 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | It is a component of the multienzyme 2-oxoglutarate dehydrogenase complex in which multiple copies of it are bound to a core of molecules of EC 2.3.1.61 (Dihydrolipoyllysine-residue succinyltransferase), which also binds multiple copies of EC 1.8.1.4 (Dihydrolipoyl dehydrogenase). Involved in the TCA cycle. | 0.895 |