node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARI_07420 | aroB | AARI_07420 | AARI_17240 | Identified by match to protein family PF02541. Similar to exopolyphosphatase (Ppx, EC 3.6.1.11) and guanosine pentaphosphate phospho-hydrolase (GppA, EC 3.6.1. 40) proteins. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.905 |
AARI_17230 | aroB | AARI_17230 | AARI_17240 | 5.2 Protein of unknown function similar to proteins from other organisms. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.796 |
AARI_17230 | aroC | AARI_17230 | AARI_17260 | 5.2 Protein of unknown function similar to proteins from other organisms. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.651 |
AARI_17230 | aroE | AARI_17230 | AARI_17270 | 5.2 Protein of unknown function similar to proteins from other organisms. | Fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone. | 0.496 |
AARI_17230 | aroK | AARI_17230 | AARI_17250 | 5.2 Protein of unknown function similar to proteins from other organisms. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.578 |
AARI_26000 | aroA | AARI_26000 | AARI_12310 | Shikimate dehydrogenase-like protein; Shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone. | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 0.961 |
AARI_26000 | aroB | AARI_26000 | AARI_17240 | Shikimate dehydrogenase-like protein; Shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.971 |
AARI_26000 | aroC | AARI_26000 | AARI_17260 | Shikimate dehydrogenase-like protein; Shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.802 |
AARI_26000 | aroE | AARI_26000 | AARI_17270 | Shikimate dehydrogenase-like protein; Shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone. | Fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone. | 0.932 |
AARI_26000 | aroK | AARI_26000 | AARI_17250 | Shikimate dehydrogenase-like protein; Shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.958 |
AARI_26000 | aroQ | AARI_26000 | AARI_25020 | Shikimate dehydrogenase-like protein; Shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone. | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. | 0.944 |
aroA | AARI_26000 | AARI_12310 | AARI_26000 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate dehydrogenase-like protein; Shikimate dehydrogenase is the fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p- aminobenzoic acid, folate and ubiquinone. | 0.961 |
aroA | aroB | AARI_12310 | AARI_17240 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | 0.991 |
aroA | aroC | AARI_12310 | AARI_17260 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.996 |
aroA | aroE | AARI_12310 | AARI_17270 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Fourth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid. Chorismic acid is a important intermediate in the synthesis of aromatic compounds, such as aromatic amino acids (phenylalanine, tyrosine and tryptophan), p-aminobenzoic acid, folate and ubiquinone. | 0.994 |
aroA | aroG | AARI_12310 | AARI_12050 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-deoxy-7-phosphoheptulonate synthase; Involved in phenylalanine, tyrosine and tryptophan biosynthesis; Belongs to the class-II DAHP synthase family. | 0.477 |
aroA | aroK | AARI_12310 | AARI_17250 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. | 0.986 |
aroA | aroQ | AARI_12310 | AARI_25020 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. | 0.457 |
aroA | tyrA | AARI_12310 | AARI_11870 | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. | Catalyses the following reaction: prephenate + NAD(+) <=> 4-hydroxyphenylpyruvate + CO(2) + NADH. Involved in tyrosine biosynthesis. | 0.643 |
aroB | AARI_07420 | AARI_17240 | AARI_07420 | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). | Identified by match to protein family PF02541. Similar to exopolyphosphatase (Ppx, EC 3.6.1.11) and guanosine pentaphosphate phospho-hydrolase (GppA, EC 3.6.1. 40) proteins. | 0.905 |