STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (300 aa)    
Predicted Functional Partners:
Glutamine amidotransferase subunit PdxT; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
Putative phosphomethylpyrimidine kinase; EC is involved in thiamin biosynthesis. It catalyzes the phosphorylation of HMP-P to HMP-PP.
Glucose-6-phosphate isomerase; Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate. Also catalyzes the anomerization of D-glucose-6-phosphate; Belongs to the GPI family.
Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily.
Putative ribokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.
Transketolase; Catalyzes the reversible transfer of a two-carbon ketol unit from xylulose 5-phosphate to ribose 5-phosphate, to form sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate. The second reaction catalyzed by transketolase involves the transfer of a 2-carbon fragment from D-xylulose 5-phosphate to the aldose D-erythrose-4-phosphate, affording fructose-6-phosphate and glyceraldehyde 3-phosphate.
Identified by match to PF00456: transketolase, thiamine diphosphate binding domain.
Identified by match to PF02779 (transketolase, pyrimidine binding domain) and PF02780 (transketolase, C-terminal domain).
Ribose-phosphate diphosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
Ribose-5-phosphate isomerase; Catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate. Involved in the pentose phosphate pathway.
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
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