node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARI_00070 | AARI_01280 | AARI_00070 | AARI_01280 | Conserved hypothetical membrane protein; 2 transmembrane helices predicted by TMHMM2.0. | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | 0.470 |
AARI_00070 | AARI_23830 | AARI_00070 | AARI_23830 | Conserved hypothetical membrane protein; 2 transmembrane helices predicted by TMHMM2.0. | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | 0.477 |
AARI_01280 | AARI_00070 | AARI_01280 | AARI_00070 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | Conserved hypothetical membrane protein; 2 transmembrane helices predicted by TMHMM2.0. | 0.470 |
AARI_01280 | AARI_23830 | AARI_01280 | AARI_23830 | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | 0.510 |
AARI_23800 | AARI_23830 | AARI_23800 | AARI_23830 | Response regulators are key elements in two-component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | 0.507 |
AARI_23800 | mshD | AARI_23800 | AARI_23810 | Response regulators are key elements in two-component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. | Putative GNAT-family acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.865 |
AARI_23800 | ppk | AARI_23800 | AARI_23820 | Response regulators are key elements in two-component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.555 |
AARI_23830 | AARI_00070 | AARI_23830 | AARI_00070 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Conserved hypothetical membrane protein; 2 transmembrane helices predicted by TMHMM2.0. | 0.477 |
AARI_23830 | AARI_01280 | AARI_23830 | AARI_01280 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms. | 0.510 |
AARI_23830 | AARI_23800 | AARI_23830 | AARI_23800 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Response regulators are key elements in two-component signal transduction systems, which enable bacteria to sense, respond, and adapt to a wide range of environments, stressors, and growth conditions. | 0.507 |
AARI_23830 | AARI_23840 | AARI_23830 | AARI_23840 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Putative GNAT-family acetyltransferase; Identified by match to PF00583: acetyltransferase (GNAT) family. | 0.508 |
AARI_23830 | AARI_34240 | AARI_23830 | AARI_34240 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | 0.537 |
AARI_23830 | folA | AARI_23830 | AARI_23860 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.452 |
AARI_23830 | mshD | AARI_23830 | AARI_23810 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Putative GNAT-family acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.669 |
AARI_23830 | nnrD | AARI_23830 | AARI_23110 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. In the C-terminal section; belongs to the NnrD/CARKD family. | 0.518 |
AARI_23830 | ppk | AARI_23830 | AARI_23820 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. | 0.891 |
AARI_23830 | thyA | AARI_23830 | AARI_23850 | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.450 |
AARI_23840 | AARI_23830 | AARI_23840 | AARI_23830 | Putative GNAT-family acetyltransferase; Identified by match to PF00583: acetyltransferase (GNAT) family. | NUDIX domain-containing protein; Identified by match to PF00293. Members of the Nudix hydrolase superfamily catalyze the hydrolysis of nucleoside diphosphates linked to other moieties. Substrates of nudix hydrolases include intact and oxidatively damaged nucleoside triphosphates, dinucleoside polyphosphates, nucleotide-sugars and dinucleotide enzymes. These substrates are metabolites or cell signaling molecules that require regulation during different stages of the cell cycle or during periods of stress. In general, the role of the nudix hydrolase is to sanitize the nucleotide pools an [...] | 0.508 |
AARI_23840 | folA | AARI_23840 | AARI_23860 | Putative GNAT-family acetyltransferase; Identified by match to PF00583: acetyltransferase (GNAT) family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.635 |
AARI_23840 | mshD | AARI_23840 | AARI_23810 | Putative GNAT-family acetyltransferase; Identified by match to PF00583: acetyltransferase (GNAT) family. | Putative GNAT-family acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. | 0.500 |