node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AARI_24150 | menA | AARI_24150 | AARI_24550 | Trans-hexaprenyltranstransferase; Produces prenyl diphosphates which act as the priming substrates for other groups of prenyl transferases. Is implicated in the biosynthesis of ubiquinone; Belongs to the FPP/GGPP synthase family. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.566 |
AARI_24150 | menF | AARI_24150 | AARI_24160 | Trans-hexaprenyltranstransferase; Produces prenyl diphosphates which act as the priming substrates for other groups of prenyl transferases. Is implicated in the biosynthesis of ubiquinone; Belongs to the FPP/GGPP synthase family. | Isochorismate synthase; Catalyses the conversion of chorismate to isochorismate, the first step in the biosynthesis of both the respiratory chain component menaquinone (MK, vitamin K2) and phylloquinone (vitamin K1): Chorismate <=> isochorismate. | 0.513 |
AARI_24150 | menG | AARI_24150 | AARI_01330 | Trans-hexaprenyltranstransferase; Produces prenyl diphosphates which act as the priming substrates for other groups of prenyl transferases. Is implicated in the biosynthesis of ubiquinone; Belongs to the FPP/GGPP synthase family. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.689 |
AARI_33920 | menA | AARI_33920 | AARI_24550 | Match to protein domain PF03061: thioesterase superfamily. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.922 |
AARI_33920 | menB | AARI_33920 | AARI_24530 | Match to protein domain PF03061: thioesterase superfamily. | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.929 |
cydDC | menA | AARI_20150 | AARI_24550 | ATP-binding cassette, subfamily C, bacterial CydCD; TCDB: ATP-binding cassette (ABC) superfamily, CydDC cysteine exporter (CydDC-E) family (TC 3.A.1.129.z). ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC)2, DPL-family, CYD-subfamily (Cytochrome bd biogenesis and cysteine export). | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.401 |
menA | AARI_24150 | AARI_24550 | AARI_24150 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Trans-hexaprenyltranstransferase; Produces prenyl diphosphates which act as the priming substrates for other groups of prenyl transferases. Is implicated in the biosynthesis of ubiquinone; Belongs to the FPP/GGPP synthase family. | 0.566 |
menA | AARI_33920 | AARI_24550 | AARI_33920 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Match to protein domain PF03061: thioesterase superfamily. | 0.922 |
menA | cydDC | AARI_24550 | AARI_20150 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | ATP-binding cassette, subfamily C, bacterial CydCD; TCDB: ATP-binding cassette (ABC) superfamily, CydDC cysteine exporter (CydDC-E) family (TC 3.A.1.129.z). ABCISSE: ABC transporter, permease and ATP-binding protein (IM-ABC)2, DPL-family, CYD-subfamily (Cytochrome bd biogenesis and cysteine export). | 0.401 |
menA | menB | AARI_24550 | AARI_24530 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.924 |
menA | menC | AARI_24550 | AARI_24220 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.668 |
menA | menD | AARI_24550 | AARI_24200 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. | 0.847 |
menA | menE | AARI_24550 | AARI_24540 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | O-succinylbenzoate-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA) : ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA. | 0.905 |
menA | menF | AARI_24550 | AARI_24160 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Isochorismate synthase; Catalyses the conversion of chorismate to isochorismate, the first step in the biosynthesis of both the respiratory chain component menaquinone (MK, vitamin K2) and phylloquinone (vitamin K1): Chorismate <=> isochorismate. | 0.679 |
menA | menG | AARI_24550 | AARI_01330 | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). | 0.932 |
menB | AARI_33920 | AARI_24530 | AARI_33920 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | Match to protein domain PF03061: thioesterase superfamily. | 0.929 |
menB | menA | AARI_24530 | AARI_24550 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.924 |
menB | menC | AARI_24530 | AARI_24220 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | O-succinylbenzoate synthase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.799 |
menB | menD | AARI_24530 | AARI_24200 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily. | 0.959 |
menB | menE | AARI_24530 | AARI_24540 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | O-succinylbenzoate-CoA ligase; Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA) : ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA. | 0.994 |