STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
xdhBXanthine dehydrogenase, molybdopterin-binding subunit; Xanthine dehydrogenase catalyses the formation of xanthine from hypoxanthine and of urate from xanthine. It is involved in purine degradation. (777 aa)    
Predicted Functional Partners:
xdhA
Xanthine dehydrogenase, iron-sulfur and FAD-binding subunit; Xanthine dehydrogenase catalyses the formation of xanthine from hypoxanthine and of urate from xanthine. It is involved in purine degradation.
 0.999
xdhC
Xanthine dehydrogenase accessory protein XdhC; Identified by match to PF02625. XdhC is believed to be involved in the attachment of molybdenum to Xanthine Dehydrogenase.
  
 0.976
AARI_33710
Urate oxidase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.
 
 
 0.933
AARI_20550
Nucleoside deaminase-like protein.
 
  
  0.918
deoD
Purine-nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
   
 
 0.914
iunH
Putative inosine/uridine-preferring nucleoside hydrolase; Catalyzes the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates.
  
  0.912
AARI_31690
Putative purine nucleosidase; Catalyzes the hydrolysis of all of the commonly occuring purine and pyrimidine nucleosides into ribose and the associated base, but has a preference for inosine and uridine as substrates.
  
  0.912
hpt
Catalyses the formation of IMP and diphosphate from hypoxanthine and 5-phospho-alpha-D-ribose 1-diphosphate. Guanine and 6-mercaptopurine can replace hypoxanthine. This enzyme is essential for salvaging exogenous purine bases; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
     
  0.900
AARI_28810
6 Protein of unknown function, without similarity to other proteins.
       0.773
AARI_33720
Putative hydroxyisourate hydrolase; Identified by match to PF00576: HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5- carboxylate (OHCU). HIU hydrolysis is the original function of the family and is conserved from bacteria to mam [...]
 
  
 0.731
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.