Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
glsA-2Glutaminase catalyzes the hydrolysis of glutamine to a glutamate and ammonia. (410 aa)    
Predicted Functional Partners:
gltB
Glutamate synthase (NADPH) subunit alpha; Glutamate synthase participates in the ammonia assimilation process by catalyzing the formation of glutamate from glutamine and 2-oxoglutarate.
     
 0.951
putA
Proline dehydrogenase (EC 1.5.99.8) catalyses the following reaction: L-proline + acceptor + H(2)O <=> (S)-1-pyrroline-5-carboxylate + reduced acceptor. Pyrroline-5-carboxylate dehydrogenase (EC 1.5.1.12) catalyses the following reaction: 1-pyrroline-5-carboxylate + NAD(+) + H(2)O <=> L-glutamate + NADH.
   
 0.912
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
    
 0.910
glnA
Glutamate--ammonia ligase, type I; Plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. The activity of class I glutamate--ammonia ligase is controlled by the adenylation of a tyrosine residue. The adenylated enzyme is inactive.
    
 0.910
glnA-2
Glutamate--ammonia ligase, type I; Plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine. The activity of class I glutamate--ammonia ligase is controlled by the adenylation of a tyrosine residue. The adenylated enzyme is inactive.
    
 0.910
glsA
Glutaminase; Catalyzes the hydrolysis of glutamine to a glutamate and ammonia; Belongs to the glutaminase family.
  
  
 
0.909
murD
UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
     
 0.908
gdhA
NADP-specific glutamate dehydrogenase; Catalyses the conversion of 2-oxoglutarate to glutamate; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
     
 0.908
gltD
Glutamate synthase (NADPH) subunit beta; Glutamate synthase participates in the ammonia assimilation process by catalyzing the formation of glutamate from glutamine and 2-oxoglutarate.
     
 0.907
glmS
Glutamine--fructose-6-phosphate transaminase (isomerizing); Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.
     
 0.904
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.