STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AARI_33710Urate oxidase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. (307 aa)    
Predicted Functional Partners:
AARI_33720
Putative hydroxyisourate hydrolase; Identified by match to PF00576: HIUase/Transthyretin family. This family includes transthyretin that is a thyroid hormone-binding protein that transports thyroxine from the bloodstream to the brain. However, most of the sequences listed in this family do not bind thyroid hormones. They are actually enzymes of the purine catabolism that catalyse the conversion of 5-hydroxyisourate (HIU) to 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5- carboxylate (OHCU). HIU hydrolysis is the original function of the family and is conserved from bacteria to mam [...]
 
 
 0.997
AARI_33730
Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms.
 
   
 0.934
xdhB
Xanthine dehydrogenase, molybdopterin-binding subunit; Xanthine dehydrogenase catalyses the formation of xanthine from hypoxanthine and of urate from xanthine. It is involved in purine degradation.
 
 
 0.933
xdhA
Xanthine dehydrogenase, iron-sulfur and FAD-binding subunit; Xanthine dehydrogenase catalyses the formation of xanthine from hypoxanthine and of urate from xanthine. It is involved in purine degradation.
 
  
  0.921
AARI_33700
Putative xanthine/uric acid permease; Nucleobase:cation symporter-2 (NCS2) Family (TC 2.A. 40.y.z). Match to protein family PF00860.
 
  
 0.839
allB
Allantoinase; Hydrolyzes allantoin into allantoate. Involved in purine degradation.
 
  
 0.838
AARI_33420
Conserved hypothetical protein; 5.2 Protein of unknown function similar to proteins from other organisms; Belongs to the HpcH/HpaI aldolase family.
 
     0.779
AARI_00560
Putative uracil/xanthine permease; Nucleobase:cation symporter-2 (NCS2) Family (TC 2.A. 40.y.z). Identified by match to protein family PF00860.
  
  
 0.486
AARI_32370
Putative hydroxypyruvate isomerase; Catalyses the following reaction: hydroxypyruvate <=> 2-hydroxy-3-oxopropanoate; Belongs to the hyi family.
 
     0.472
AARI_10400
Match to protein domain PF00266: aminotransferase class-V. This domain is found in aminotransferases, and other enzymes, including cysteine desulphurase.
  
  
 0.456
Your Current Organism:
Glutamicibacter arilaitensis
NCBI taxonomy Id: 861360
Other names: Arthrobacter arilaitensis CIP 108037, Arthrobacter arilaitensis Re117, G. arilaitensis Re117, Glutamicibacter arilaitensis Re117
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.