node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EFM25859.1 | EFM26366.1 | HMPREF9225_0403 | HMPREF9225_0060 | Glycosyltransferase, group 1 family protein; Pfam: PF00534; InterPro: IPR001296. | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.645 |
EFM25887.1 | EFM26366.1 | HMPREF9225_0431 | HMPREF9225_0060 | PP-loop family protein; COG: COG0037; Pfam: PF01171; InterPro: IPR014729; Belongs to the TtcA family. | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.692 |
EFM26363.1 | EFM26366.1 | HMPREF9225_0057 | HMPREF9225_0060 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.803 |
EFM26363.1 | tagO | HMPREF9225_0057 | HMPREF9225_0059 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Glycosyltransferase, group 4 family; COG: COG0472; Pfam: PF00953; InterPro: IPR000715. | 0.798 |
EFM26363.1 | upp | HMPREF9225_0057 | HMPREF9225_0058 | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.809 |
EFM26366.1 | EFM25859.1 | HMPREF9225_0060 | HMPREF9225_0403 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Glycosyltransferase, group 1 family protein; Pfam: PF00534; InterPro: IPR001296. | 0.645 |
EFM26366.1 | EFM25887.1 | HMPREF9225_0060 | HMPREF9225_0431 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | PP-loop family protein; COG: COG0037; Pfam: PF01171; InterPro: IPR014729; Belongs to the TtcA family. | 0.692 |
EFM26366.1 | EFM26363.1 | HMPREF9225_0060 | HMPREF9225_0057 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Sua5/YciO/YrdC/YwlC family protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.803 |
EFM26366.1 | glmU | HMPREF9225_0060 | HMPREF9225_1712 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | 0.913 |
EFM26366.1 | mraY | HMPREF9225_0060 | HMPREF9225_1217 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.659 |
EFM26366.1 | murA | HMPREF9225_0060 | HMPREF9225_0147 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.893 |
EFM26366.1 | tagA | HMPREF9225_0060 | HMPREF9225_1571 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Glycosyltransferase, WecB/TagA/CpsF family; Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid. | 0.719 |
EFM26366.1 | tagO | HMPREF9225_0060 | HMPREF9225_0059 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Glycosyltransferase, group 4 family; COG: COG0472; Pfam: PF00953; InterPro: IPR000715. | 0.963 |
EFM26366.1 | tilS | HMPREF9225_0060 | HMPREF9225_1421 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | tRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. | 0.692 |
EFM26366.1 | upp | HMPREF9225_0060 | HMPREF9225_0058 | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.799 |
glmU | EFM26366.1 | HMPREF9225_1712 | HMPREF9225_0060 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.913 |
glmU | mraY | HMPREF9225_1712 | HMPREF9225_1217 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | 0.518 |
glmU | murA | HMPREF9225_1712 | HMPREF9225_0147 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. | 0.933 |
glmU | tagO | HMPREF9225_1712 | HMPREF9225_0059 | UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. | Glycosyltransferase, group 4 family; COG: COG0472; Pfam: PF00953; InterPro: IPR000715. | 0.518 |
mraY | EFM26366.1 | HMPREF9225_1217 | HMPREF9225_0060 | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. | UDP-N-acetylglucosamine 2-epimerase; COG: COG0381; Pfam: PF02350; InterPro: IPR003331; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. | 0.659 |