| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BMS_0006 | atpB | BMS_0006 | BMS_0009 | Putative TPR repeat lipoprotein. | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | 0.780 |
| BMS_0006 | dnaN | BMS_0006 | BMS_0002 | Putative TPR repeat lipoprotein. | Putative DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | 0.657 |
| BMS_0006 | gyrA | BMS_0006 | BMS_0005 | Putative TPR repeat lipoprotein. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.779 |
| BMS_0006 | gyrB | BMS_0006 | BMS_0004 | Putative TPR repeat lipoprotein. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.762 |
| BMS_0006 | recF | BMS_0006 | BMS_0003 | Putative TPR repeat lipoprotein. | Putative DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.675 |
| BMS_1255 | dnaK | BMS_1255 | BMS_3243 | Putative DNA gyrase subunit A. | Chaperone protein dnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.621 |
| BMS_1255 | gyrB | BMS_1255 | BMS_0004 | Putative DNA gyrase subunit A. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.997 |
| BMS_1255 | oxaA | BMS_1255 | BMS_3448 | Putative DNA gyrase subunit A. | Membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.457 |
| BMS_1255 | polA | BMS_1255 | BMS_0277 | Putative DNA gyrase subunit A. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.562 |
| BMS_1255 | rpoB | BMS_1255 | BMS_3310 | Putative DNA gyrase subunit A. | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.433 |
| atpB | BMS_0006 | BMS_0009 | BMS_0006 | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | Putative TPR repeat lipoprotein. | 0.780 |
| atpB | dnaN | BMS_0009 | BMS_0002 | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | Putative DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initia [...] | 0.692 |
| atpB | gyrA | BMS_0009 | BMS_0005 | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.863 |
| atpB | gyrB | BMS_0009 | BMS_0004 | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.817 |
| atpB | oxaA | BMS_0009 | BMS_3448 | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | Membrane protein OxaA; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.681 |
| atpB | recF | BMS_0009 | BMS_0003 | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | Putative DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. | 0.675 |
| atpB | rpoB | BMS_0009 | BMS_3310 | ATP synthase A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. | DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.428 |
| dnaK | BMS_1255 | BMS_3243 | BMS_1255 | Chaperone protein dnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Putative DNA gyrase subunit A. | 0.621 |
| dnaK | gyrA | BMS_3243 | BMS_0005 | Chaperone protein dnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.811 |
| dnaK | gyrB | BMS_3243 | BMS_0004 | Chaperone protein dnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.811 |
