Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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dnaKChaperone protein dnaK (HSP70); Acts as a chaperone; Belongs to the heat shock protein 70 family. (642 aa)    
Predicted Functional Partners:
dnaJ
Chaperone protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK a [...]
 0.999
grpE
Protein grpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]
 
 0.999
groL
60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.990
htpG
Chaperone protein (heat shock protein).
  
 0.989
BMS_2874
Putative heat shock-like protein.
  
 0.975
groS
10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
  
 
 0.972
clpB
ClpB protein (heat shock protein f84.1); Belongs to the ClpA/ClpB family.
  
 
 0.961
clpA
Putative ATP-dependent Clp protease ATP-binding subunit; Belongs to the ClpA/ClpB family.
  
 
 0.961
BMS_0867
Putative exported protein.
  
 0.899
rpsB
30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family.
  
 0.867
Your Current Organism:
Halobacteriovorax marinus
NCBI taxonomy Id: 862908
Other names: Bacteriovorax marinus SJ, Bdellovibrio sp. SJ, H. marinus SJ, Halobacteriovorax marinus SJ
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