Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lacDTagatose 1,6-diphosphate aldolase; Belongs to the aldolase LacD family. (333 aa)    
Predicted Functional Partners:
lacC
Fructose-1-phosphate/tagatose-6-phosphate kinase-like protein; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
 
 
 0.933
agaS
Putative sugar isomerase domain protein.
 
   
 0.910
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
    
 0.910
SCI_1845
Hypothetical protein.
    
  0.906
SCI_1902
Hypothetical protein.
    
  0.906
lacD1
Tagatose 1,6-diphosphate aldolase; Belongs to the aldolase LacD family.
  
  
 
0.903
galM
Putative aldose 1-epimerase; Converts alpha-aldose to the beta-anomer.
  
  
 0.819
SCI_1640
Putative 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase.
     
  0.800
codY
GTP-sensing transcriptional pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.750
lacE
PTS system, lactose-specific IIBC component.
 
  
 0.725
Your Current Organism:
Streptococcus constellatus
NCBI taxonomy Id: 862969
Other names: S. constellatus subsp. pharyngis C1050, Streptococcus constellatus subsp. pharyngis C1050, Streptococcus constellatus subsp. pharyngis str. C1050, Streptococcus constellatus subsp. pharyngis strain C1050
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