Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lcdbetaC-S lyase. (388 aa)    
Predicted Functional Partners:
metB
Cystathionine gamma-synthase.
 
 
 0.995
cysK
Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
    
 0.928
metE
Methyltransferase protein; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 0.906
luxS
S-ribosylhomocysteinase; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
     
 0.905
hom
Homoserine dehydrogenase.
    
 0.809
pepN
Aminopeptidase N.
    
  0.801
coaB
Phosphopantothenate-cysteine ligase.
    
  0.801
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
  0.800
gshA
Glutamate-cysteine ligase; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine; In the N-terminal section; belongs to the glutamate--cysteine ligase type 1 family. Type 2 subfamily.
     
  0.800
SANR_0482
Putative polysaccharide biosynthesis/transport protein.
       0.642
Your Current Organism:
Streptococcus anginosus
NCBI taxonomy Id: 862971
Other names: S. anginosus C238, Streptococcus anginosus C238, Streptococcus anginosus str. C238, Streptococcus anginosus strain C238
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