Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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dnaK-2Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (867 aa)    
Predicted Functional Partners:
grpE
Molecular chaperone GrpE (heat shock protein); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. [...]
 
 0.986
EKQ69055.1
DnaJ-class molecular chaperone with C-terminal Zn finger domain; IMG reference gene:2510095331; PFAM: DnaJ C terminal region; DnaJ domain.
 
 0.984
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 0.965
EKQ70905.1
DnaJ-class molecular chaperone with C-terminal Zn finger domain; IMG reference gene:2510094883; PFAM: DnaJ domain.
  
 0.961
EKQ70056.1
Molecular chaperone of HSP90 family; IMG reference gene:2510093989; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Hsp90 protein.
  
 0.955
EKQ67306.1
DnaJ-class molecular chaperone with C-terminal Zn finger domain; IMG reference gene:2510097230; PFAM: DnaJ domain; DnaJ C terminal region.
  
 0.951
EKQ67965.1
DnaJ-class molecular chaperone with C-terminal Zn finger domain; IMG reference gene:2510097933; PFAM: DnaJ C terminal region; DnaJ domain.
  
 0.951
groL
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.941
groL-2
Chaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 0.941
EKQ70195.1
WD40 repeat-containing protein; IMG reference gene:2510094138; PFAM: DnaJ domain; WD domain, G-beta repeat; Tetratricopeptide repeat.
 
 0.913
Your Current Organism:
Oscillatoriales cyanobacterium JSC12
NCBI taxonomy Id: 864702
Other names: O. cyanobacterium JSC-12, Oscillatoriales cyanobacterium JSC-12
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