STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADX68027.1COGs: COG0188 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) A subunit; InterPro IPR002205; KEGG: fbc:FB2170_10771 DNA topoisomerase IV subunit A; PFAM: DNA topoisomerase, type IIA, subunit A/C-terminal; PRIAM: DNA topoisomerase (ATP-hydrolyzing); SMART: DNA topoisomerase, type IIA, subunit A/C-terminal; SPTR: DNA topoisomerase 4 subunit A; PFAM: DNA gyrase/topoisomerase IV, subunit A. (847 aa)    
Predicted Functional Partners:
ADX68025.1
COGs: COG0187 Type IIA topoisomerase (DNA gyrase/topo II topoisomerase IV) B subunit; InterPro IPR003594:IPR001241:IPR013506:IPR006171; KEGG: fba:FIC_01276 DNA topoisomerase IV subunit B; PFAM: DNA topoisomerase, type IIA, subunit B, domain 2; ATPase-like, ATP-binding domain; Toprim domain; SMART: DNA topoisomerase, type IIA, subunit B/N-terminal; ATPase-like, ATP-binding domain; SPTR: DNA topoisomerase (ATP-hydrolyzing) subunit B; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; DNA gyrase B; DNA gyrase B subunit, carboxyl terminus.
 
 0.993
gyrB
DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
 0.948
ADX68028.1
Peptidase S54, rhomboid domain protein; InterPro IPR022764; KEGG: zpr:ZPR_1738 rhomboid family protein; PFAM: Peptidase S54, rhomboid domain; SPTR: Rhomboid family protein; PFAM: Rhomboid family.
       0.785
ADX68026.1
KEGG: gfo:GFO_1480 membrane protein; SPTR: Putative uncharacterized protein.
       0.777
secD
Protein-export membrane protein SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily.
 
  
 0.747
metG
Methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
  
  
 0.726
argS
COGs: COG0018 Arginyl-tRNA synthetase; HAMAP: Arginyl-tRNA synthetase, class Ic; InterPro IPR001278:IPR008909:IPR005148:IPR015945; KEGG: coc:Coch_0186 arginyl-tRNA synthetase; PFAM: DALR anticodon binding; Arginyl-tRNA synthetase, class Ic, core; Arginyl tRNA synthetase, class Ic, N-terminal; PRIAM: Arginine--tRNA ligase; SMART: DALR anticodon binding; SPTR: Arginyl-tRNA synthetase; TIGRFAM: Arginyl-tRNA synthetase, class Ic; PFAM: DALR anticodon binding domain; Arginyl tRNA synthetase N terminal domain; tRNA synthetases class I (R); TIGRFAM: arginyl-tRNA synthetase.
 
  
 0.557
nusA
NusA antitermination factor; Participates in both transcription termination and antitermination.
  
  
 0.532
ADX68021.1
COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterPro IPR002701:IPR006218:IPR020822; KEGG: fba:FIC_01361 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase I beta; PFAM: DAHP synthetase I/KDSA; Chorismate mutase, type II; PRIAM: 3-deoxy-7-phosphoheptulonate synthase; SMART: Chorismate mutase; SPTR:2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase I beta; PFAM: Chorismate mutase type II; DAHP synthetase I family; TIGRFAM: chorismate mutase related enzymes; phospho-2-dehydro-3-deoxyheptonate aldolase.
  
  
 0.524
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.505
Your Current Organism:
Weeksella virosa
NCBI taxonomy Id: 865938
Other names: W. virosa DSM 16922, Weeksella virosa ATCC 43766, Weeksella virosa CIP 103040, Weeksella virosa DSM 16922, Weeksella virosa str. DSM 16922, Weeksella virosa strain DSM 16922
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