STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ADX68741.1Oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (374 aa)    
Predicted Functional Partners:
ADX68061.1
COGs: COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductase; InterPro IPR006638:IPR007197:IPR010723:IPR004558; KEGG: fbc:FB2170_03835 coproporphyrinogen III oxidase; PFAM: HemN, C-terminal; Radical SAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: Possible coproporphyrinogen dehydrogenase; TIGRFAM: Oxygen-independent coproporphyrinogen III oxidase HemN; PFAM: Radical SAM superfamily; HemN C-terminal region; TIGRFAM: oxygen-independent coproporphyrinogen III oxidase; Belongs to the anaerobic coproporphyrinogen-III oxidase family.
  
  
 
0.922
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.919
ADX68187.1
Uncharacterized protein family UPF0093; COGs: COG1981 membrane protein; InterPro IPR005265; KEGG: coc:Coch_1332 hypothetical protein; PFAM: Uncharacterised protein family UPF0093; SPTR: Putative uncharacterized protein; PFAM: Uncharacterised protein family (UPF0093); TIGRFAM: conserved hypothetical integral membrane protein.
    
 0.914
ADX67543.1
COGs: COG3278 Cbb3-type cytochrome oxidase subunit 1; InterPro IPR000883:IPR003468:IPR004677; KEGG: fba:FIC_00146 cytochrome c oxidase subunit CcoN; PFAM: Cytochrome c oxidase, monohaem subunit/FixO; Cytochrome c oxidase, subunit I; PRIAM: Cytochrome-c oxidase; SPTR: Cytochrome c oxidase; TIGRFAM: Cytochrome c oxidase cbb3-type, subunit I; Cytochrome c oxidase, monohaem subunit/FixO; PFAM: Cytochrome C oxidase, mono-heme subunit/FixO; Cytochrome C and Quinol oxidase polypeptide I; TIGRFAM: cytochrome c oxidase, cbb3-type, subunit II; cytochrome c oxidase, cbb3-type, subunit I; Belongs [...]
  
  
 0.818
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
    0.780
lepA
GTP-binding protein lepA; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner.
  
 0.764
rlmN
Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family.
 
   
 0.701
ADX68287.1
Nucleoside-triphosphatase rdgB; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.562
ADX68743.1
Heat shock protein DnaJ domain protein; COGs: COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain; InterPro IPR001623:IPR002939; KEGG: bfs:BF3207 putative chaperone; PFAM: Heat shock protein DnaJ, N-terminal; Chaperone DnaJ, C-terminal; SMART: Heat shock protein DnaJ, N-terminal; SPTR: Putative chaperone; PFAM: DnaJ domain; DnaJ C terminal region.
  
    0.525
ADX68739.1
COGs: COG4992 Ornithine/acetylornithine aminotransferase; InterPro IPR005814:IPR010164; KEGG: fps:FP0739 ornithine--oxo-acid transaminase; PFAM: Aminotransferase class-III; PRIAM: Ornithine aminotransferase; SPTR: Ornithine--oxo-acid transaminase; TIGRFAM: Ornithine aminotransferase; PFAM: Aminotransferase class-III; TIGRFAM: ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
       0.515
Your Current Organism:
Weeksella virosa
NCBI taxonomy Id: 865938
Other names: W. virosa DSM 16922, Weeksella virosa ATCC 43766, Weeksella virosa CIP 103040, Weeksella virosa DSM 16922, Weeksella virosa str. DSM 16922, Weeksella virosa strain DSM 16922
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