STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CHD8Chromodomain helicase DNA binding protein. (1743 aa)    
Predicted Functional Partners:
POB3
FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...]
    
 
 0.916
RPB3
45 kDa subunit of RNA polymerase II.
   
 0.887
HHT1_2
Histone H3; Belongs to the histone H3 family.
    
 0.858
HHT1_4
Histone H3; Belongs to the histone H3 family.
    
 0.858
MPH1
3'-5' DNA helicase.
    
 0.851
SPT16
FACT complex subunit spt16.
    
 
 0.850
HTA1
Histone H2A; Belongs to the histone H2A family.
    
 0.839
POLR2L
DNA-directed RNA polymerases I, II, and III subunit RPABC5.
    
  0.836
RPC10
DNA-directed RNA polymerase core subunit rpc10.
    
  0.835
RPB5
DNA-directed RNA polymerases II 24 kDa polypeptide (RNA polymerase II subunit 5).
    
  0.835
Your Current Organism:
Rhizopus azygosporus
NCBI taxonomy Id: 86630
Other names: ATCC 48108, CBS 357.93, R. azygosporus, Rhizopus microsporus var. azygosporus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.