STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDI99037.1Uncharacterized conserved protein YecE, DUF72 family. (282 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.787
SDI99054.1
Uncharacterized protein.
       0.776
SDI99094.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
       0.772
SDJ18958.1
Hypothetical protein.
 
    0.614
tatA
Sec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
       0.454
SDI98978.1
RNase HI.
 
     0.445
SDI99012.1
Cold-shock DNA-binding protein family.
       0.437
SDI97585.1
Uncharacterized protein YpbB.
  
     0.429
SDJ71353.1
Transcriptional regulator; Belongs to the CtsR family.
  
     0.415
Your Current Organism:
Salimicrobium halophilum
NCBI taxonomy Id: 86666
Other names: ATCC 49085, Bacillus halophilus, CCM 4074, DSM 4771, HAMBI 2106, JCM 12305, LMG 17942, LMG:17942, NBRC 102426, S. halophilum, strain N23-2
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.