| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MTCT_0115 | MTCT_0229 | MTCT_0115 | MTCT_0229 | Nicotinamide-nucleotide adenylyltransferase. | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.597 |
| MTCT_0115 | MTCT_1007 | MTCT_0115 | MTCT_1007 | Nicotinamide-nucleotide adenylyltransferase. | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.724 |
| MTCT_0115 | MTCT_1364 | MTCT_0115 | MTCT_1364 | Nicotinamide-nucleotide adenylyltransferase. | Conserved hypothetical protein. | 0.600 |
| MTCT_0115 | pfdB | MTCT_0115 | MTCT_0606 | Nicotinamide-nucleotide adenylyltransferase. | Conserved hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.435 |
| MTCT_0115 | tiaS | MTCT_0115 | MTCT_0877 | Nicotinamide-nucleotide adenylyltransferase. | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.597 |
| MTCT_0229 | MTCT_0115 | MTCT_0229 | MTCT_0115 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Nicotinamide-nucleotide adenylyltransferase. | 0.597 |
| MTCT_0229 | MTCT_1007 | MTCT_0229 | MTCT_1007 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.618 |
| MTCT_0229 | MTCT_1364 | MTCT_0229 | MTCT_1364 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Conserved hypothetical protein. | 0.642 |
| MTCT_0229 | tiaS | MTCT_0229 | MTCT_0877 | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | Conserved hypothetical protein; ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA. | 0.626 |
| MTCT_1005 | MTCT_1007 | MTCT_1005 | MTCT_1007 | Putative phosphatidylglycerophosphatase. | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | 0.877 |
| MTCT_1005 | cobS | MTCT_1005 | MTCT_1006 | Putative phosphatidylglycerophosphatase. | Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.955 |
| MTCT_1005 | upp | MTCT_1005 | MTCT_1008 | Putative phosphatidylglycerophosphatase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.470 |
| MTCT_1007 | MTCT_0115 | MTCT_1007 | MTCT_0115 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Nicotinamide-nucleotide adenylyltransferase. | 0.724 |
| MTCT_1007 | MTCT_0229 | MTCT_1007 | MTCT_0229 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). | 0.618 |
| MTCT_1007 | MTCT_1005 | MTCT_1007 | MTCT_1005 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Putative phosphatidylglycerophosphatase. | 0.877 |
| MTCT_1007 | MTCT_1364 | MTCT_1007 | MTCT_1364 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein. | 0.638 |
| MTCT_1007 | MTCT_1521 | MTCT_1007 | MTCT_1521 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein. | 0.946 |
| MTCT_1007 | cobS | MTCT_1007 | MTCT_1006 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. | 0.924 |
| MTCT_1007 | pfdB | MTCT_1007 | MTCT_0606 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | Conserved hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.702 |
| MTCT_1007 | tgtA | MTCT_1007 | MTCT_0143 | Conserved hypothetical protein; Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs; Belongs to the aTrm56 family. | tRNA-guanine transglycosylase; Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs; Belongs to the archaeosine tRNA-ribosyltransferase family. | 0.659 |