STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ADY29772.1Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (165 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
 
 0.999
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.925
fmt
Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
 
 0.924
purH
Phosphoribosylaminoimidazole carboxamideformyltransferase; COGs: COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful); InterPro IPR011607: IPR013982; KEGG: fbc:FB2170_08559 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; PFAM: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; PRIAM: Phosphoribosylaminoimidazolecarboxamide formyltransferase; SMART: AICARFT/IMPCHase bienzyme, transformylase domain; Methylglyoxal synthase-like domain; SPTR: Bifunctional phosphoribosylami [...]
    
 0.918
purN
Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
   
 
 0.918
ADY29864.1
FolC bifunctional protein; COGs: COG0285 Folylpolyglutamate synthase; InterPro IPR001645: IPR013221; KEGG: fbc:FB2170_17411 folylpolyglutamate synthase; PFAM: Mur ligase, central; PRIAM: Tetrahydrofolate synthase; SPTR: Folylpolyglutamate synthase; TIGRFAM: Folylpolyglutamate synthetase; PFAM: Mur ligase middle domain; TIGRFAM: folylpolyglutamate synthase/dihydrofolate synthase.
     
 0.918
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.917
purU
Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).
    
 0.912
ADY29798.1
COGs: COG0646 Methionine synthase I (cobalamin-dependent) methyltransferase domain; InterPro IPR003726; KEGG: fbc:FB2170_17141 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Homocysteine S-methyltransferase; PRIAM: Methionine synthase; SPTR: 5-methyltetrahydrofolate--homocysteine methyltransferase; PFAM: Homocysteine S-methyltransferase.
    
 0.912
ADY28524.1
COGs: COG3186 Phenylalanine-4-hydroxylase; InterPro IPR019774; KEGG: rbi:RB2501_09225 phenylalanine 4-monooxygenase; PFAM: Aromatic amino acid hydroxylase, C-terminal; PRIAM: Phenylalanine 4-monooxygenase; SPTR: Putative uncharacterized protein; PFAM: Biopterin-dependent aromatic amino acid hydroxylase.
     
 0.901
Your Current Organism:
Cellulophaga lytica
NCBI taxonomy Id: 867900
Other names: C. lytica DSM 7489, Cellulophaga lytica ATCC 23178, Cellulophaga lytica DSM 7489, Cellulophaga lytica IAM 14306, Cellulophaga lytica str. DSM 7489, Cellulophaga lytica strain DSM 7489
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