AFL98165.1 protein (Ornithobacterium rhinotracheale)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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Experiments

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[Homology]

Score

AFL98165.1

Hypothetical protein. (125 aa)

Predicted Functional Partners:

AFL98164.1

0.934

AFL98163.1

0.928

AFL98170.1

0.836

AFL98158.1

0.801

AFL98171.1

0.793

AFL98172.1

0.793

AFL98176.1

0.788

AFL98188.1

0.785

AFL98193.1

0.778

AFL98194.1

0.765

Your Current Organism:

Ornithobacterium rhinotracheale

NCBI taxonomy Id: 867902
Other names: O. rhinotracheale DSM 15997, Ornithobacterium rhinotracheale DSM 15997, Ornithobacterium rhinotracheale LMG 9086, Ornithobacterium rhinotracheale str. DSM 15997, Ornithobacterium rhinotracheale strain DSM 15997

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFL98158.1	AFL98163.1	Ornrh_2023	Ornrh_2028	Hypothetical protein.	TIGRFAM: Bacteroides conjugative transposon TraN protein.	0.831
AFL98158.1	AFL98164.1	Ornrh_2023	Ornrh_2029	Hypothetical protein.	PFAM: Protein of unknown function (DUF3714); TIGRFAM: Bacteroides conjugative transposon TraM protein.	0.825
AFL98158.1	AFL98165.1	Ornrh_2023	Ornrh_2030	Hypothetical protein.	Hypothetical protein.	0.801
AFL98158.1	AFL98170.1	Ornrh_2023	Ornrh_2035	Hypothetical protein.	Hypothetical protein.	0.741
AFL98158.1	AFL98171.1	Ornrh_2023	Ornrh_2036	Hypothetical protein.	Hypothetical protein.	0.766
AFL98158.1	AFL98172.1	Ornrh_2023	Ornrh_2037	Hypothetical protein.	Hypothetical protein.	0.722
AFL98158.1	AFL98176.1	Ornrh_2023	Ornrh_2042	Hypothetical protein.	PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.	0.772
AFL98158.1	AFL98188.1	Ornrh_2023	Ornrh_2056	Hypothetical protein.	Helicase family protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.	0.735
AFL98158.1	AFL98193.1	Ornrh_2023	Ornrh_2061	Hypothetical protein.	Hypothetical protein.	0.770
AFL98163.1	AFL98158.1	Ornrh_2028	Ornrh_2023	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Hypothetical protein.	0.831
AFL98163.1	AFL98164.1	Ornrh_2028	Ornrh_2029	TIGRFAM: Bacteroides conjugative transposon TraN protein.	PFAM: Protein of unknown function (DUF3714); TIGRFAM: Bacteroides conjugative transposon TraM protein.	0.932
AFL98163.1	AFL98165.1	Ornrh_2028	Ornrh_2030	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Hypothetical protein.	0.928
AFL98163.1	AFL98170.1	Ornrh_2028	Ornrh_2035	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Hypothetical protein.	0.824
AFL98163.1	AFL98171.1	Ornrh_2028	Ornrh_2036	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Hypothetical protein.	0.789
AFL98163.1	AFL98172.1	Ornrh_2028	Ornrh_2037	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Hypothetical protein.	0.792
AFL98163.1	AFL98176.1	Ornrh_2028	Ornrh_2042	TIGRFAM: Bacteroides conjugative transposon TraN protein.	PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain.	0.788
AFL98163.1	AFL98188.1	Ornrh_2028	Ornrh_2056	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Helicase family protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.	0.782
AFL98163.1	AFL98193.1	Ornrh_2028	Ornrh_2061	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Hypothetical protein.	0.791
AFL98163.1	AFL98194.1	Ornrh_2028	Ornrh_2062	TIGRFAM: Bacteroides conjugative transposon TraN protein.	Hypothetical protein.	0.769
AFL98164.1	AFL98158.1	Ornrh_2029	Ornrh_2023	PFAM: Protein of unknown function (DUF3714); TIGRFAM: Bacteroides conjugative transposon TraM protein.	Hypothetical protein.	0.825

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.826

expected number of edges:

11

PPI enrichment p-value:

3.13e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006836

Neurotransmitter transport

7 of 137

2.03

3.96

8.35e-10

GO:0098700

Neurotransmitter loading into synaptic vesicle

4 of 10

2.92

3.92

6.00e-08

GO:0099504

Synaptic vesicle cycle

6 of 127

2.0

3.25

6.00e-08

GO:0001505

Regulation of neurotransmitter levels

5 of 178

1.77

2.1

1.79e-05

GO:0017156

Calcium-ion regulated exocytosis

3 of 42

2.18

1.57

0.0010

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015495

Gamma-aminobutyric acid:proton symporter activity

3 of 3

3.32

2.97

4.36e-06

GO:0015187

Glycine transmembrane transporter activity

3 of 6

3.02

2.77

9.14e-06

GO:0015294

Solute:cation symporter activity

4 of 132

1.8

1.79

0.00014

GO:0016413

O-acetyltransferase activity

2 of 12

2.54

1.35

0.0034

GO:0042910

Xenobiotic transmembrane transporter activity

2 of 25

2.22

1.1

0.0089

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043679

Axon terminus

5 of 56

2.27

3.78

2.09e-08

GO:0051286

Cell tip

3 of 3

3.32

3.61

2.89e-07

GO:0048786

Presynaptic active zone

5 of 70

2.18

3.6

3.02e-08

GO:0044292

Dendrite terminus

3 of 8

2.9

3.18

1.47e-06

GO:0098793

Presynapse

8 of 405

1.62

2.93

9.78e-10

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23104

Mixed, incl. Norepinephrine Neurotransmitter Release Cycle, and Vesicle fusion to plasma membrane

8 of 65

2.41

6.74

5.33e-15

CL:23106

Norepinephrine Neurotransmitter Release Cycle, and Vesicle fusion to plasma membrane

5 of 58

2.26

3.74

2.36e-08

CL:23108

Mixed, incl. Vesicle fusion to plasma membrane, and Serotonin Neurotransmitter Release Cycle

3 of 32

2.29

1.96

0.00019

CL:23162

Mixed, incl. Acetate ester transmembrane transporter activity, and Cell tip

2 of 5

2.92

1.56

0.0015

CL:27951

Acyltransferase ChoActase/COT/CPT, and Glycerophosphodiester phosphodiesterase domain

2 of 12

2.54

1.21

0.0060

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-112310

Neurotransmitter release cycle

8 of 112

2.18

5.63

1.15e-13

MAP-888590

GABA synthesis, release, reuptake and degradation

5 of 42

2.4

4.11

7.17e-09

MAP-264642

Acetylcholine Neurotransmitter Release Cycle

4 of 37

2.36

3.09

9.36e-07

MAP-112315

Transmission across Chemical Synapses

8 of 454

1.57

2.7

3.18e-09

MAP-112316

Neuronal System

8 of 696

1.38

2.05

4.59e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0044292

Dendrite terminus

3 of 9

2.84

2.75

8.99e-06

GOCC:0098793

Presynapse

6 of 197

1.81

2.73

2.93e-07

GOCC:0030285

Integral component of synaptic vesicle membrane

3 of 14

2.65

2.53

2.08e-05

GOCC:0030658

Transport vesicle membrane

4 of 89

1.97

2.22

2.40e-05

GOCC:0045202

Synapse

7 of 545

1.43

1.93

1.00e-06

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01490

Transmembrane amino acid transporter protein

3 of 15

2.62

2.07

0.00015

PF02318

FYVE-type zinc finger

2 of 12

2.54

0.91

0.0218

PF00755

Choline/Carnitine o-acyltransferase

2 of 12

2.54

0.91

0.0218

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR013057

Amino acid transporter, transmembrane domain

3 of 17

2.57

1.73

0.00066

IPR004734

Multidrug resistance protein

2 of 4

3.02

1.08

0.0111

IPR039032

Rim-like

2 of 7

2.78

0.97

0.0177

IPR042231

Choline/Carnitine o-acyltransferase, domain 2

2 of 11

2.58

0.85

0.0288

IPR041282

FYVE-type zinc finger

2 of 12

2.54

0.85

0.0288

(more ...)

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