AFL98348.1 protein (Ornithobacterium rhinotracheale)

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second shell of interactors

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Predicted Interactions

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Score

AFL98348.1

Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336). (165 aa)

Predicted Functional Partners:

AFL98349.1

0.840

AFL98347.1

0.822

AFL98346.1

0.594

AFL96749.1

0.577

AFL97971.1

0.569

AFL98350.1

0.561

AFL97368.1

0.559

AFL98351.1

0.415

Your Current Organism:

Ornithobacterium rhinotracheale

NCBI taxonomy Id: 867902
Other names: O. rhinotracheale DSM 15997, Ornithobacterium rhinotracheale DSM 15997, Ornithobacterium rhinotracheale LMG 9086, Ornithobacterium rhinotracheale str. DSM 15997, Ornithobacterium rhinotracheale strain DSM 15997

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFL96749.1	AFL97368.1	Ornrh_0547	Ornrh_1183	PFAM: BNR/Asp-box repeat; Fibronectin type III domain; TIGRFAM: Por secretion system C-terminal sorting domain.	Hypothetical protein.	0.776
AFL96749.1	AFL98347.1	Ornrh_0547	Ornrh_2216	PFAM: BNR/Asp-box repeat; Fibronectin type III domain; TIGRFAM: Por secretion system C-terminal sorting domain.	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	0.419
AFL96749.1	AFL98348.1	Ornrh_0547	Ornrh_2217	PFAM: BNR/Asp-box repeat; Fibronectin type III domain; TIGRFAM: Por secretion system C-terminal sorting domain.	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	0.577
AFL97368.1	AFL96749.1	Ornrh_1183	Ornrh_0547	Hypothetical protein.	PFAM: BNR/Asp-box repeat; Fibronectin type III domain; TIGRFAM: Por secretion system C-terminal sorting domain.	0.776
AFL97368.1	AFL97971.1	Ornrh_1183	Ornrh_1822	Hypothetical protein.	Hypothetical protein.	0.776
AFL97368.1	AFL98348.1	Ornrh_1183	Ornrh_2217	Hypothetical protein.	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	0.559
AFL97971.1	AFL97368.1	Ornrh_1822	Ornrh_1183	Hypothetical protein.	Hypothetical protein.	0.776
AFL97971.1	AFL98348.1	Ornrh_1822	Ornrh_2217	Hypothetical protein.	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	0.569
AFL98346.1	AFL98347.1	Ornrh_2215	Ornrh_2216	Hypothetical protein.	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	0.594
AFL98346.1	AFL98348.1	Ornrh_2215	Ornrh_2217	Hypothetical protein.	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	0.594
AFL98346.1	AFL98349.1	Ornrh_2215	Ornrh_2218	Hypothetical protein.	Hydroxyisourate hydrolase; PFAM: HIUase/Transthyretin family; TIGRFAM: hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.	0.516
AFL98346.1	AFL98350.1	Ornrh_2215	Ornrh_2219	Hypothetical protein.	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	0.441
AFL98347.1	AFL96749.1	Ornrh_2216	Ornrh_0547	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	PFAM: BNR/Asp-box repeat; Fibronectin type III domain; TIGRFAM: Por secretion system C-terminal sorting domain.	0.419
AFL98347.1	AFL98346.1	Ornrh_2216	Ornrh_2215	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	Hypothetical protein.	0.594
AFL98347.1	AFL98348.1	Ornrh_2216	Ornrh_2217	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	0.822
AFL98347.1	AFL98349.1	Ornrh_2216	Ornrh_2218	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	Hydroxyisourate hydrolase; PFAM: HIUase/Transthyretin family; TIGRFAM: hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.	0.793
AFL98347.1	AFL98350.1	Ornrh_2216	Ornrh_2219	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	Transketolase, alpha subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.	0.561
AFL98347.1	AFL98351.1	Ornrh_2216	Ornrh_2220	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	PFAM: Copper resistance protein D.	0.415
AFL98348.1	AFL96749.1	Ornrh_2217	Ornrh_0547	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	PFAM: BNR/Asp-box repeat; Fibronectin type III domain; TIGRFAM: Por secretion system C-terminal sorting domain.	0.577
AFL98348.1	AFL97368.1	Ornrh_2217	Ornrh_1183	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol; PFAM: Domain of unknown function (DUF336).	Hypothetical protein.	0.559

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Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.764

expected number of edges:

31

PPI enrichment p-value:

0.768

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016579

Protein deubiquitination

6 of 58

2.25

4.1

3.09e-09

GO:1903051

Negative regulation of proteolysis involved in protein catabolic process

3 of 12

2.63

2.18

9.31e-05

GO:0006511

Ubiquitin-dependent protein catabolic process

5 of 299

1.46

1.38

0.00036

GO:0030162

Regulation of proteolysis

4 of 240

1.45

1.08

0.0032

GO:0007094

Mitotic spindle assembly checkpoint signaling

2 of 15

2.36

1.05

0.0114

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004843

Cysteine-type deubiquitinase activity

5 of 48

2.25

3.42

1.26e-07

GO:0004197

Cysteine-type endopeptidase activity

5 of 71

2.08

3.16

2.01e-07

GO:0140096

Catalytic activity, acting on a protein

6 of 1524

0.83

0.51

0.0219

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005634

Nucleus

9 of 3640

0.63

0.42

0.0151

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9211

Mixed, incl. Peptidase C19, ubiquitin carboxyl-terminal hydrolase, and HELP motif

6 of 12

2.93

6.63

3.60e-13

CL:9129

Processing of Intronless Pre-mRNAs, and Peptidase C19, ubiquitin carboxyl-terminal hydrolase

7 of 53

2.35

5.7

9.91e-13

CL:9214

Regulation of protein localization to cell surface, and Peptidase C19, ubiquitin carboxyl-terminal hydrolase

4 of 6

3.06

4.33

1.14e-08

CL:5274

Mixed, incl. Male germ-line stem cell asymmetric division, and Meiotic sister chromatid cohesion

2 of 6

2.75

1.24

0.0056

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5689880

Ub-specific processing proteases

4 of 182

1.57

1.11

0.0039

MAP-5688426

Deubiquitination

4 of 250

1.44

0.96

0.0068

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

2 of 18

2.28

0.86

0.0266

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

2 of 18

2.28

0.86

0.0266

MAP-179409

APC-Cdc20 mediated degradation of Nek2A

2 of 22

2.19

0.85

0.0266

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13423

Ubiquitin carboxyl-terminal hydrolase

3 of 13

2.6

2.16

0.00010

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001394

Peptidase C19, ubiquitin carboxyl-terminal hydrolase

4 of 22

2.49

2.88

3.41e-06

IPR028889

Ubiquitin specific protease domain

4 of 24

2.45

2.87

3.41e-06

IPR038765

Papain-like cysteine peptidase superfamily

5 of 101

1.93

2.52

3.41e-06

IPR018200

Ubiquitin specific protease, conserved site

3 of 20

2.41

1.93

0.00024

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