| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB48420.1 | AGB49129.1 | Metho_0132 | Metho_0886 | Isocitrate/isopropylmalate dehydrogenase. | Isopropylmalate/homocitrate/citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.582 |
| AGB48420.1 | AGB49974.1 | Metho_0132 | Metho_1790 | Isocitrate/isopropylmalate dehydrogenase. | TIGRFAM: acetolactate synthase, small subunit. | 0.966 |
| AGB48420.1 | AGB50111.1 | Metho_0132 | Metho_1936 | Isocitrate/isopropylmalate dehydrogenase. | Isopropylmalate/homocitrate/citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.567 |
| AGB48420.1 | hacB | Metho_0132 | Metho_0481 | Isocitrate/isopropylmalate dehydrogenase. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.781 |
| AGB48420.1 | ilvC | Metho_0132 | Metho_1789 | Isocitrate/isopropylmalate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.556 |
| AGB48420.1 | leuC | Metho_0132 | Metho_0194 | Isocitrate/isopropylmalate dehydrogenase. | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.990 |
| AGB48420.1 | leuC-2 | Metho_0132 | Metho_0694 | Isocitrate/isopropylmalate dehydrogenase. | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.794 |
| AGB48746.1 | AGB48747.1 | Metho_0479 | Metho_0480 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Hypothetical protein. | 0.822 |
| AGB48746.1 | AGB48749.1 | Metho_0479 | Metho_0482 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Putative membrane protein, required for N-linked glycosylation; TIGRFAM: oligosaccharyl transferase, archaeosortase system-associated. | 0.773 |
| AGB48746.1 | AGB49129.1 | Metho_0479 | Metho_0886 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Isopropylmalate/homocitrate/citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.966 |
| AGB48746.1 | AGB49974.1 | Metho_0479 | Metho_1790 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | TIGRFAM: acetolactate synthase, small subunit. | 0.682 |
| AGB48746.1 | AGB50111.1 | Metho_0479 | Metho_1936 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Isopropylmalate/homocitrate/citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.578 |
| AGB48746.1 | hacB | Metho_0479 | Metho_0481 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.994 |
| AGB48746.1 | ilvC | Metho_0479 | Metho_1789 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.583 |
| AGB48746.1 | leuC | Metho_0479 | Metho_0194 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.918 |
| AGB48746.1 | leuC-2 | Metho_0479 | Metho_0694 | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.984 |
| AGB48747.1 | AGB48746.1 | Metho_0480 | Metho_0479 | Hypothetical protein. | TIGRFAM: isopropylmalate/isohomocitrate dehydrogenases. | 0.822 |
| AGB48747.1 | AGB48749.1 | Metho_0480 | Metho_0482 | Hypothetical protein. | Putative membrane protein, required for N-linked glycosylation; TIGRFAM: oligosaccharyl transferase, archaeosortase system-associated. | 0.886 |
| AGB48747.1 | AGB49129.1 | Metho_0480 | Metho_0886 | Hypothetical protein. | Isopropylmalate/homocitrate/citramalate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.542 |
| AGB48747.1 | hacB | Metho_0480 | Metho_0481 | Hypothetical protein. | 3-isopropylmalate dehydratase, small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD [...] | 0.937 |
