| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB48917.1 | AGB49175.1 | Metho_0661 | Metho_0933 | Thymidylate synthase. | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.901 |
| AGB48917.1 | pyrG | Metho_0661 | Metho_1424 | Thymidylate synthase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.468 |
| AGB48917.1 | surE | Metho_0661 | Metho_0467 | Thymidylate synthase. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.920 |
| AGB48917.1 | tmk | Metho_0661 | Metho_1720 | Thymidylate synthase. | TIGRFAM: thymidylate kinase. | 0.946 |
| AGB49175.1 | AGB48917.1 | Metho_0933 | Metho_0661 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Thymidylate synthase. | 0.901 |
| AGB49175.1 | AGB49388.1 | Metho_0933 | Metho_1154 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | 0.901 |
| AGB49175.1 | AGB49883.1 | Metho_0933 | Metho_1694 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Sugar kinase, ribokinase; Belongs to the carbohydrate kinase PfkB family. | 0.909 |
| AGB49175.1 | AGB50275.1 | Metho_0933 | Metho_2110 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | TIGRFAM: anaerobic ribonucleoside-triphosphate reductase. | 0.902 |
| AGB49175.1 | ndk | Metho_0933 | Metho_1518 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. | 0.913 |
| AGB49175.1 | pyrF | Metho_0933 | Metho_0780 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Orotidine 5''-phosphate decarboxylase, subfamily 1; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.901 |
| AGB49175.1 | pyrG | Metho_0933 | Metho_1424 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.909 |
| AGB49175.1 | pyrH | Metho_0933 | Metho_0126 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.906 |
| AGB49175.1 | surE | Metho_0933 | Metho_0467 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.901 |
| AGB49175.1 | tmk | Metho_0933 | Metho_1720 | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | TIGRFAM: thymidylate kinase. | 0.913 |
| AGB49388.1 | AGB49175.1 | Metho_1154 | Metho_0933 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.901 |
| AGB49388.1 | AGB49883.1 | Metho_1154 | Metho_1694 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | Sugar kinase, ribokinase; Belongs to the carbohydrate kinase PfkB family. | 0.913 |
| AGB49388.1 | pyrF | Metho_1154 | Metho_0780 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | Orotidine 5''-phosphate decarboxylase, subfamily 1; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.916 |
| AGB49388.1 | pyrH | Metho_1154 | Metho_0126 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.915 |
| AGB49388.1 | surE | Metho_1154 | Metho_0467 | AMP phosphorylase; Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily. | 5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.952 |
| AGB49883.1 | AGB49175.1 | Metho_1694 | Metho_0933 | Sugar kinase, ribokinase; Belongs to the carbohydrate kinase PfkB family. | MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. | 0.909 |
