Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cdhBCO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase. The precise role of the epsilon subunit is unclear; it may have a stabilizing role within the alpha(2)epsilon(2) component and/or be involved in electron transfer to FAD during a potential FAD- mediated CO oxidation. (169 aa)    
Predicted Functional Partners:
cdhA
CO dehydrogenase/acetyl-CoA synthase complex, epsilon subunit; Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase.
 
 0.999
cdhC
CO dehydrogenase/CO-methylating acetyl-CoA synthase complex, beta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex).
 
 0.999
cdhD
CO dehydrogenase/acetyl-CoA synthase, delta subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.
 
 
 0.998
cdhE
CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein); Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.
 
 
 0.997
AGB49217.1
CO dehydrogenase maturation factor.
 
    0.989
AGB49993.1
CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein).
 
 
 0.982
AGB49621.1
TIGRFAM: carbon-monoxide dehydrogenase, catalytic subunit.
     
 0.904
AGB49991.1
Formylmethanofuran dehydrogenase subunit D.
 
  
 0.877
AGB48981.1
Formylmethanofuran dehydrogenase subunit D.
 
  
 0.876
AGB49315.1
NADH:ubiquinone oxidoreductase chain I-like protein.
 
  
  0.853
Your Current Organism:
Methanomethylovorans hollandica
NCBI taxonomy Id: 867904
Other names: M. hollandica DSM 15978, Methanomethylovorans hollandica DMS1, Methanomethylovorans hollandica DSM 15978, Methanomethylovorans hollandica str. DSM 15978, Methanomethylovorans hollandica strain DSM 15978
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.