Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (325 aa)    
Predicted Functional Partners:
AGB48756.1
TIGRFAM: mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 2 family.
 
 
 0.957
AGB48923.1
Nucleoside-diphosphate-sugar pyrophosphorylase family protein; TIGRFAM: glucose-1-phosphate thymidylylransferase, long form.
    
 0.917
AGB50151.1
TIGRFAM: UDP-N-acetylglucosamine 2-epimerase.
  
  
 0.608
hpt
PRPP-binding protein, adenine/guanine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily.
    
   0.584
AGB49913.1
Nucleoside-diphosphate-sugar epimerase.
 
 
 0.560
AGB49509.1
ABC-type polysaccharide/polyol phosphate transport system, ATPase component.
 
  
 0.517
AGB50148.1
TIGRFAM: exodeoxyribonuclease VII, small subunit.
       0.511
AGB49508.1
ABC-type polysaccharide/polyol phosphate export systems, permease component.
 
  
 0.510
AGB50149.1
TIGRFAM: exodeoxyribonuclease VII, large subunit.
       0.510
AGB49687.1
Nucleoside-diphosphate-sugar epimerase; Manually curated; non-canonical start codon.
  
 
 0.502
Your Current Organism:
Methanomethylovorans hollandica
NCBI taxonomy Id: 867904
Other names: M. hollandica DSM 15978, Methanomethylovorans hollandica DMS1, Methanomethylovorans hollandica DSM 15978, Methanomethylovorans hollandica str. DSM 15978, Methanomethylovorans hollandica strain DSM 15978
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