| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB48964.1 | AGB49164.1 | Metho_0714 | Metho_0922 | TIGRFAM: phosphomethylpyrimidine kinase. | TIGRFAM: 6,7-dimethyl-8-ribityllumazine synthase. | 0.622 |
| AGB48964.1 | purM | Metho_0714 | Metho_2084 | TIGRFAM: phosphomethylpyrimidine kinase. | TIGRFAM: phosphoribosylaminoimidazole synthetase. | 0.559 |
| AGB48964.1 | rsgA | Metho_0714 | Metho_1307 | TIGRFAM: phosphomethylpyrimidine kinase. | Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.913 |
| AGB48964.1 | thiE | Metho_0714 | Metho_1590 | TIGRFAM: phosphomethylpyrimidine kinase. | Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
| AGB48964.1 | thiL | Metho_0714 | Metho_2113 | TIGRFAM: phosphomethylpyrimidine kinase. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.984 |
| AGB49164.1 | AGB48964.1 | Metho_0922 | Metho_0714 | TIGRFAM: 6,7-dimethyl-8-ribityllumazine synthase. | TIGRFAM: phosphomethylpyrimidine kinase. | 0.622 |
| AGB49164.1 | purM | Metho_0922 | Metho_2084 | TIGRFAM: 6,7-dimethyl-8-ribityllumazine synthase. | TIGRFAM: phosphoribosylaminoimidazole synthetase. | 0.465 |
| AGB49164.1 | thiL | Metho_0922 | Metho_2113 | TIGRFAM: 6,7-dimethyl-8-ribityllumazine synthase. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.640 |
| AGB49284.1 | adk | Metho_1047 | Metho_2001 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Adenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | 0.745 |
| AGB49284.1 | purL | Metho_1047 | Metho_2278 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | 0.991 |
| AGB49284.1 | purM | Metho_1047 | Metho_2084 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | TIGRFAM: phosphoribosylaminoimidazole synthetase. | 0.942 |
| AGB49284.1 | thiL | Metho_1047 | Metho_2113 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.768 |
| AGB49284.1 | valS | Metho_1047 | Metho_1867 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.878 |
| AGB50279.1 | thiL | Metho_2114 | Metho_2113 | TIGRFAM: S-layer-related duplication domain. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.893 |
| adk | AGB49284.1 | Metho_2001 | Metho_1047 | Adenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.745 |
| adk | rsgA | Metho_2001 | Metho_1307 | Adenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. | 0.901 |
| adk | thiL | Metho_2001 | Metho_2113 | Adenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. | 0.904 |
| adk | valS | Metho_2001 | Metho_1867 | Adenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.697 |
| purL | AGB49284.1 | Metho_2278 | Metho_1047 | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.991 |
| purL | purM | Metho_2278 | Metho_2084 | Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...] | TIGRFAM: phosphoribosylaminoimidazole synthetase. | 0.998 |
