| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB49108.1 | AGB49284.1 | Metho_0865 | Metho_1047 | Indole-3-glycerol phosphate synthase. | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | 0.521 |
| AGB49108.1 | AGB50345.1 | Metho_0865 | Metho_2182 | Indole-3-glycerol phosphate synthase. | TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. | 0.999 |
| AGB49108.1 | aroC | Metho_0865 | Metho_1004 | Indole-3-glycerol phosphate synthase. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.557 |
| AGB49108.1 | trpA | Metho_0865 | Metho_0862 | Indole-3-glycerol phosphate synthase. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.999 |
| AGB49108.1 | trpB | Metho_0865 | Metho_0863 | Indole-3-glycerol phosphate synthase. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.999 |
| AGB49108.1 | trpB-2 | Metho_0865 | Metho_1857 | Indole-3-glycerol phosphate synthase. | Pyridoxal-phosphate dependent TrpB-like enzyme; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.962 |
| AGB49108.1 | trpD | Metho_0865 | Metho_2185 | Indole-3-glycerol phosphate synthase. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.998 |
| AGB49108.1 | trpE | Metho_0865 | Metho_2183 | Indole-3-glycerol phosphate synthase. | Anthranilate synthase component I, archaeal clade; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate a [...] | 0.999 |
| AGB49108.1 | trpF | Metho_0865 | Metho_2184 | Indole-3-glycerol phosphate synthase. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.999 |
| AGB49284.1 | AGB49108.1 | Metho_1047 | Metho_0865 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Indole-3-glycerol phosphate synthase. | 0.521 |
| AGB49284.1 | AGB50345.1 | Metho_1047 | Metho_2182 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. | 0.862 |
| AGB49284.1 | aroC | Metho_1047 | Metho_1004 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.625 |
| AGB49284.1 | trpA | Metho_1047 | Metho_0862 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.742 |
| AGB49284.1 | trpB | Metho_1047 | Metho_0863 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.663 |
| AGB49284.1 | trpD | Metho_1047 | Metho_2185 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.662 |
| AGB49284.1 | trpE | Metho_1047 | Metho_2183 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Anthranilate synthase component I, archaeal clade; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate a [...] | 0.594 |
| AGB49284.1 | trpF | Metho_1047 | Metho_2184 | metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein; TIGRFAM: MJ0570-related uncharacterized domain; TIGR00289 family protein; asparagine synthase (glutamine-hydrolyzing); arCOG00187 universal archaeal metal-binding-domain/4Fe-4S-binding-domain containing ABC transporter, ATP-binding protein. | Phosphoribosylanthranilate isomerase; Belongs to the TrpF family. | 0.828 |
| AGB50344.1 | AGB50345.1 | Metho_2181 | Metho_2182 | Putative nucleoside kinase, CMP and AMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | TIGRFAM: glutamine amidotransferase of anthranilate synthase or aminodeoxychorismate synthase. | 0.917 |
| AGB50344.1 | trpD | Metho_2181 | Metho_2185 | Putative nucleoside kinase, CMP and AMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.917 |
| AGB50344.1 | trpE | Metho_2181 | Metho_2183 | Putative nucleoside kinase, CMP and AMP kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. | Anthranilate synthase component I, archaeal clade; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate a [...] | 0.917 |
