| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGB50042.1 | AGB50352.1 | Metho_1862 | Metho_2189 | TIGRFAM: uroporphyrin-III C-methyltransferase. | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.937 |
| AGB50042.1 | AGB50353.1 | Metho_1862 | Metho_2190 | TIGRFAM: uroporphyrin-III C-methyltransferase. | TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.445 |
| AGB50042.1 | AGB50356.1 | Metho_1862 | Metho_2193 | TIGRFAM: uroporphyrin-III C-methyltransferase. | TIGRFAM: precorrin-3B C17-methyltransferase. | 0.565 |
| AGB50042.1 | cbiT | Metho_1862 | Metho_2188 | TIGRFAM: uroporphyrin-III C-methyltransferase. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.530 |
| AGB50042.1 | cbiX | Metho_1862 | Metho_0734 | TIGRFAM: uroporphyrin-III C-methyltransferase. | Hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.657 |
| AGB50042.1 | cobQ | Metho_1862 | Metho_2187 | TIGRFAM: uroporphyrin-III C-methyltransferase. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.406 |
| AGB50352.1 | AGB50042.1 | Metho_2189 | Metho_1862 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.937 |
| AGB50352.1 | AGB50353.1 | Metho_2189 | Metho_2190 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.998 |
| AGB50352.1 | AGB50354.1 | Metho_2189 | Metho_2191 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein CbiG; Manually curated; non-canonical start codon. | 0.991 |
| AGB50352.1 | AGB50355.1 | Metho_2189 | Metho_2192 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein CbiG. | 0.976 |
| AGB50352.1 | AGB50356.1 | Metho_2189 | Metho_2193 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: precorrin-3B C17-methyltransferase. | 0.999 |
| AGB50352.1 | AGB50357.1 | Metho_2189 | Metho_2194 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Precorrin isomerase. | 0.996 |
| AGB50352.1 | cbiD | Metho_2189 | Metho_2294 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.951 |
| AGB50352.1 | cbiT | Metho_2189 | Metho_2188 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin-7. | 0.996 |
| AGB50352.1 | cbiX | Metho_2189 | Metho_0734 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Hypothetical protein; Catalyzes the insertion of Co(2+) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2+) into sirohydrochlorin to yield Ni- sirohydrochlorin. | 0.969 |
| AGB50352.1 | cobQ | Metho_2189 | Metho_2187 | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.980 |
| AGB50353.1 | AGB50042.1 | Metho_2190 | Metho_1862 | TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: uroporphyrin-III C-methyltransferase. | 0.445 |
| AGB50353.1 | AGB50352.1 | Metho_2190 | Metho_2189 | TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | TIGRFAM: precorrin-2 C20-methyltransferase; Belongs to the precorrin methyltransferase family. | 0.998 |
| AGB50353.1 | AGB50354.1 | Metho_2190 | Metho_2191 | TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein CbiG; Manually curated; non-canonical start codon. | 0.998 |
| AGB50353.1 | AGB50355.1 | Metho_2190 | Metho_2192 | TIGRFAM: precorrin-4 C11-methyltransferase; Belongs to the precorrin methyltransferase family. | Cobalamin biosynthesis protein CbiG. | 0.996 |
