Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AGB50579.1PFAM: Dihydrouridine synthase (Dus); TIGRFAM: putative TIM-barrel protein, nifR3 family. (329 aa)    
Predicted Functional Partners:
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
  
  
 0.657
truA
Pseudouridylate synthase I; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
 
 
 0.579
AGB50583.1
2-oxoacid:ferredoxin oxidoreductase, beta subunit; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
     
 0.503
AGB50580.1
PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family.
     
 0.500
AGB50582.1
2-oxoacid:ferredoxin oxidoreductase, alpha subunit; PFAM: domain; Transketolase, C-terminal domain.
     
 0.500
AGB50581.1
TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family.
     
 0.488
trm1
tRNA(guanine-26,N2-N2) methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
   
 
 0.466
truB
rRNA pseudouridine synthase, putative; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.
 
  
 0.460
AGB49175.1
MAF protein; Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
 
   
 0.458
AGB48847.1
TIGRFAM: MiaB-like tRNA modifying enzyme, archaeal-type; radical SAM methylthiotransferase, MiaB/RimO family; manually curated.
 
  
 0.437
Your Current Organism:
Methanomethylovorans hollandica
NCBI taxonomy Id: 867904
Other names: M. hollandica DSM 15978, Methanomethylovorans hollandica DMS1, Methanomethylovorans hollandica DSM 15978, Methanomethylovorans hollandica str. DSM 15978, Methanomethylovorans hollandica strain DSM 15978
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