Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
AEG17831.1Tetratricopeptide TPR_1 repeat-containing protein; PFAM: Tetratricopeptide TPR-1; KEGG: mmg:MTBMA_c15910 tetratricopeptide repeat domain-containing protein. (163 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein dnaK; Acts as a chaperone.
  
 0.734
dnaJ
Chaperone protein dnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 0.723
rpoH
DNA-directed RNA polymerase subunit H; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.
  
 0.711
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
   
 0.699
rpoD
DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
 0.693
AEG17504.1
RNA polymerase Rbp10; KEGG: mmg:MTBMA_c10670 DNA-directed RNA polymerase II, subunit RPC10; manually curated; SMART: RNA polymerase Rbp10.
  
 0.678
AEG19094.1
PFAM: Histone deacetylase superfamily; KEGG: mfv:Mfer_0399 histone deacetylase.
   
 0.672
AEG19398.1
PFAM: Peptidyl-prolyl cis-trans isomerase, cyclophilin-type; KEGG: rci:RCIX757 peptidyl-prolyl cis-trans isomerase B (cyclophilin type).
  
 
 0.653
AEG18447.1
RNA polymerase, N/8 Kd subunit; KEGG: mmg:MTBMA_c05305 DNA-directed RNA polymerase subunit N; manually curated; PFAM: RNA polymerases, N/8kDa subunit.
    
 0.650
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
  
 
 0.641
Your Current Organism:
Methanobacterium paludis
NCBI taxonomy Id: 868131
Other names: DSM 25820, JCM 18151, M. paludis, Methanobacterium paludis Cadillo-Quiroz et al. 2014, Methanobacterium sp. SWAN1, strain SWAN1
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