Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEG18050.1PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; KEGG: mst:Msp_0487 homoserine dehydrogenase. (337 aa)    
Predicted Functional Partners:
AEG17760.1
KEGG: mmg:MTBMA_c11980 aspartate kinase; TIGRFAM: Aspartate kinase region; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family.
 
 0.986
asd-2
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
 0.983
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.938
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.937
metXA
Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.
 
 
 0.935
AEG17788.1
KEGG: mmg:MTBMA_c03910 homoserine O-acetyltransferase; PFAM: Alpha/beta hydrolase fold-1.
  
 
 0.926
AEG19149.1
PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: mmg:MTBMA_c16200 homoserine dehydrogenase.
  
  
 
0.911
AEG17689.1
Protein of unknown function DUF39; KEGG: mmg:MTBMA_c12520 CBS domain containing protein; PFAM: Protein of unknown function DUF39; Cystathionine beta-synthase, core; SMART: Cystathionine beta-synthase, core.
     
 0.904
AEG17489.1
PFAM: Methionine synthase, vitamin-B12 independent; KEGG: mfv:Mfer_0256 methionine synthase (b12-independent).
 
 
 0.902
AEG17688.1
NIL domain-containing protein; PFAM: NIL domain; 4Fe-4S ferredoxin, iron-sulphur binding, subgroup; KEGG: mmg:MTBMA_c12510 conserved hypothetical protein containing a ferredoxin domain.
     
  0.900
Your Current Organism:
Methanobacterium paludis
NCBI taxonomy Id: 868131
Other names: DSM 25820, JCM 18151, M. paludis, Methanobacterium paludis Cadillo-Quiroz et al. 2014, Methanobacterium sp. SWAN1, strain SWAN1
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