Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEF94840.1PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: drm:Dred_1165 homoserine dehydrogenase. (435 aa)    
Predicted Functional Partners:
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
  
 0.999
asd
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
  
 0.983
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
 
 0.958
AEF94838.1
KEGG: drm:Dred_1167 aspartate kinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family.
 
 0.957
AEF94453.1
Methionine synthase; KEGG: drm:Dred_2207 homocysteine S-methyltransferase; PFAM: Homocysteine S-methyltransferase; Pterin-binding; Methionine synthase, cobalamin (vitamin B12)-binding module, cap; Cobalamin (vitamin B12)-binding.
  
 
 0.950
AEF95316.1
TIGRFAM: Threonine synthase; KEGG: drm:Dred_0615 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
  
 
 0.931
AEF92994.1
PFAM: Domain of unknown function DUF39; KEGG: drm:Dred_0101 hypothetical protein.
     
  0.900
AEF92995.1
NIL domain-containing protein; KEGG: drm:Dred_0102 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein; PFAM: NIL domain; 4Fe-4S binding domain; SMART: NIL domain.
     
  0.900
AEF93753.1
TIGRFAM: Threonine synthase; KEGG: drm:Dred_1379 threonine synthase; PFAM: Pyridoxal phosphate-dependent enzyme, beta subunit.
 
 
 0.891
AEF94330.1
KEGG: drm:Dred_1940 aspartate kinase I; TIGRFAM: Aspartate kinase, monofunctional class; Aspartate kinase domain; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family.
 
 
 0.884
Your Current Organism:
Desulfotomaculum nigrificans
NCBI taxonomy Id: 868595
Other names: D. nigrificans CO-1-SRB, Desulfotomaculum carboxydivorans CO-1-SRB, Desulfotomaculum carboxydivorans DSM 14880, Desulfotomaculum nigrificans CO-1-SRB
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