Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEF94841.1UPF0735 ACT domain-containing protein; KEGG: drm:Dred_1164 hypothetical protein; HAMAP: Ligand-binding-predicted, ACT; PFAM: Amino acid-binding ACT; Belongs to the UPF0735 family. (148 aa)    
Predicted Functional Partners:
AEF93832.1
PFAM: Prephenate dehydratase; Amino acid-binding ACT; Chorismate mutase, type II; KEGG: dae:Dtox_0905 prephenate dehydratase; SMART: Chorismate mutase.
  
 
 0.925
AEF94857.1
Manually curated; KEGG: drm:Dred_1150 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase.
     
 0.906
AEF94538.1
TIGRFAM: Anthranilate synthase, glutamine amidotransferase domain; KEGG: drm:Dred_0249 glutamine amidotransferase of anthranilate synthase; PFAM: Glutamine amidotransferase class-I, C-terminal.
     
  0.900
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
     
  0.900
AEF94863.1
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
     
  0.900
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
     
  0.900
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
     0.834
AEF94840.1
PFAM: Homoserine dehydrogenase, catalytic; Aspartate/homoserine dehydrogenase, NAD-binding; Amino acid-binding ACT; KEGG: drm:Dred_1165 homoserine dehydrogenase.
       0.804
mqnA
Protein of unknown function DUF178; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).
     
  0.800
AEF94838.1
KEGG: drm:Dred_1167 aspartate kinase; TIGRFAM: Aspartate kinase domain; Aspartate kinase, monofunctional class; PFAM: Aspartate/glutamate/uridylate kinase; Amino acid-binding ACT; Belongs to the aspartokinase family.
     
 0.624
Your Current Organism:
Desulfotomaculum nigrificans
NCBI taxonomy Id: 868595
Other names: D. nigrificans CO-1-SRB, Desulfotomaculum carboxydivorans CO-1-SRB, Desulfotomaculum carboxydivorans DSM 14880, Desulfotomaculum nigrificans CO-1-SRB
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