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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AEF94857.1Manually curated; KEGG: drm:Dred_1150 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (302 aa)    
Predicted Functional Partners:
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
  
 0.998
AEF93832.1
PFAM: Prephenate dehydratase; Amino acid-binding ACT; Chorismate mutase, type II; KEGG: dae:Dtox_0905 prephenate dehydratase; SMART: Chorismate mutase.
 
 0.984
hisC
PFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: drm:Dred_2354 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 
 0.978
cmk
TIGRFAM: Cytidylate kinase; HAMAP: Cytidylate kinase; KEGG: drm:Dred_1152 cytidylate kinase; PFAM: Cytidylate kinase domain; Shikimate kinase.
 
  
 0.950
AEF94859.1
KEGG: drm:Dred_1148 aspartate aminotransferase; PFAM: Aminotransferase, class I/classII.
  
 
 0.934
AEF94863.1
Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
  
 
  0.933
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.911
AEF94135.1
Aspartate transaminase; KEGG: drm:Dred_1696 aminotransferase, class I and II; PFAM: Aminotransferase, class I/classII.
  
 
 0.909
AEF94841.1
UPF0735 ACT domain-containing protein; KEGG: drm:Dred_1164 hypothetical protein; HAMAP: Ligand-binding-predicted, ACT; PFAM: Amino acid-binding ACT; Belongs to the UPF0735 family.
     
 0.906
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
 
  
 0.830
Your Current Organism:
Desulfotomaculum nigrificans
NCBI taxonomy Id: 868595
Other names: D. nigrificans CO-1-SRB, Desulfotomaculum carboxydivorans CO-1-SRB, Desulfotomaculum carboxydivorans DSM 14880, Desulfotomaculum nigrificans CO-1-SRB
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