STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (279 aa)    
Predicted Functional Partners:
ADY73315.1
NAD(+) synthase (glutamine-hydrolyzing); COGs: COG0388 amidohydrolase; InterPro IPR003010; KEGG: gme:Gmet_2863 nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; PRIAM: NAD(+) synthase (glutamine-hydrolyzing); SPTR: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; PFAM: Carbon-nitrogen hydrolase.
   
 0.994
nadD
Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.951
nadK
Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
 
  
 0.946
cobB
COGs: COG0846 NAD-dependent protein deacetylase SIR2 family; HAMAP: NAD-dependent deacetylase; InterPro IPR003000; KEGG: pab:PAB0801 NAD-dependent deacetylase; PFAM: NAD-dependent histone deacetylase, silent information regulator Sir2; SPTR: NAD-dependent deacetylase; PFAM: Sir2 family; Belongs to the sirtuin family. Class III subfamily.
    
 0.922
ADY73312.1
COGs: COG0518 GMP synthase - Glutamine amidotransferase domain; InterPro IPR000991; KEGG: hya:HY04AAS1_1393 glutamine amidotransferase class-I; PFAM: Glutamine amidotransferase class-I, C-terminal; SPTR: Glutamine amidotransferase class-I; PFAM: Glutamine amidotransferase class-I.
     
 0.800
ADY73313.1
Peptidase U62 modulator of DNA gyrase; COGs: COG0312 Zn-dependent protease and their inactivated homologs; InterPro IPR002510; KEGG: tal:Thal_0403 peptidase U62 modulator of DNA gyrase; PFAM: Peptidase U62, modulator of DNA gyrase; SPTR: Peptidase U62 modulator of DNA gyrase; PFAM: Putative modulator of DNA gyrase.
       0.773
ADY73316.1
Surface antigen variable number repeat-containing protein; COGs: COG4775 Outer membrane protein/protective antigen OMA87; InterPro IPR010827; KEGG: fbc:FB2170_08359 outer membrane surface antigen protein; PFAM: Surface antigen variable number; SPTR: Outer membrane surface antigen protein; PFAM: Surface antigen variable number repeat.
       0.773
ADY73063.1
Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.
  
  
 0.586
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
     
 0.522
ADY74045.1
Chorismate mutase; COGs: COG0077 Prephenate dehydratase; InterPro IPR010958: IPR010957: IPR020822: IPR001086: IPR 002912; KEGG: aae:aq_951 chorismate mutase/prephenate dehydratase; PFAM: Prephenate dehydratase; Chorismate mutase, type II; Amino acid-binding ACT; SPTR: P-protein; TIGRFAM: Gamma/beta/epsilon proteobacterial P-protein, chorismate mutase domain; Chorismate mutase, high GC Gram-positive bacteria/archaeal; PFAM: Prephenate dehydratase; Chorismate mutase type II; ACT domain; TIGRFAM: chorismate mutase domain of T-protein; chorismate mutase domain of gram positive AroA protein [...]
     
 0.521
Your Current Organism:
Desulfurobacterium thermolithotrophum
NCBI taxonomy Id: 868864
Other names: D. thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum BSA, Desulfurobacterium thermolithotrophum DSM 11699, Desulfurobacterium thermolithotrophum str. DSM 11699, Desulfurobacterium thermolithotrophum strain DSM 11699
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.