STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB10790.1COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR011294:IPR002198; KEGG: mrb:Mrub_1680 3-hydroxybutyrate dehydrogenase; PFAM: Short-chain dehydrogenase/reductase SDR; PRIAM: 3-hydroxybutyrate dehydrogenase; SPTR: 3-hydroxybutyrate dehydrogenase; TIGRFAM: 3-hydroxybutyrate dehydrogenase; IMG reference gene:2504659588; PFAM: short chain dehydrogenase; TIGRFAM: 3-hydroxybutyrate dehydrogenase. (253 aa)    
Predicted Functional Partners:
AEB11663.1
Hydroxymethylglutaryl-CoA lyase; COGs: COG0119 Isopropylmalate/homocitrate/citramalate synthase; InterPro IPR000891; KEGG: ttj:TTHA1526 hydroxymethylglutaryl-CoA lyase like protein; PFAM: Pyruvate carboxyltransferase; PRIAM: Hydroxymethylglutaryl-CoA lyase; SPTR: Hydroxymethylglutaryl-CoA lyase; IMG reference gene:2504660506; PFAM: HMGL-like.
   
 
 0.902
AEB11286.1
Short-chain dehydrogenase/reductase SDR; COGs: COG4221 Short-chain alcohol dehydrogenase of unknown specificity; InterPro IPR002198; KEGG: pfu:PF0074 alcohol dehydrogenase, short chain; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Alcohol dehydrogenase, short chain; IMG reference gene:2504660120; PFAM: short chain dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  
    0.763
AEB10834.1
Short-chain dehydrogenase/reductase SDR; COGs: COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase); InterPro IPR002198; KEGG: msv:Mesil_0043 short-chain dehydrogenase/reductase SDR; PFAM: Short-chain dehydrogenase/reductase SDR; SPTR: Short-chain dehydrogenase/reductase SDR; manually curated; IMG reference gene:2504659638; PFAM: short chain dehydrogenase.
  
     0.617
AEB11591.1
COGs: COG0331 (acyl-carrier-protein) S-malonyltransferase; InterPro IPR004410:IPR020801:IPR014043; KEGG: ttj:TTHA0416 malonyl CoA-[acyl carrier protein] transacylase; PFAM: Acyl transferase; PRIAM: [Acyl-carrier-protein] S-malonyltransferase; SMART: Polyketide synthase, acyl transferase domain; SPTR: Malonyl CoA-acyl carrier protein transacylase; TIGRFAM: Malonyl CoA-acyl carrier protein transacylase; IMG reference gene:2504660433; PFAM: Acyl transferase domain; TIGRFAM: malonyl CoA-acyl carrier protein transacylase.
 
 
 0.557
menC
O-succinylbenzoic acid (OSB) synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB).
  
  
 0.550
AEB11685.1
Transcriptional regulator, DeoR family; COGs: COG1349 Transcriptional regulators of sugar metabolism; InterPro IPR001034:IPR014036; KEGG: mrb:Mrub_1701 DeoR family transcriptional regulator; PFAM: HTH transcriptional regulator, DeoR; HTH transcriptional regulator, DeoR N-terminal; SMART: HTH transcriptional regulator, DeoR N-terminal; SPTR: Transcriptional regulator, DeoR family; IMG reference gene:2504660530; PFAM: Bacterial regulatory proteins, deoR family; DeoR-like helix-turn-helix domain.
  
  
 0.514
sbcD
Nuclease SbcCD, D subunit; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity; Belongs to the SbcD family.
   
 
 0.509
AEB10934.1
ATP-dependent DNA helicase, RecQ family; COGs: COG0514 Superfamily II DNA helicase; InterProIPR004589:IPR006055:IPR014001:IPR006554:IPR 006555:IPR001650:IPR013520:IPR006935:IPR011545; KEGG: msv:Mesil_3363 hypothetical protein; PFAM: Helicase, C-terminal; DNA/RNA helicase, DEAD/DEAH box type, N-terminal; Exonuclease, RNase T/DNA polymerase III; Restriction endonuclease, type I, R subunit/Type III, Res subunit; SMART: Exonuclease; DEAD-like helicase, N-terminal; Helicase-like, DEXD box c2 type; Helicase, ATP-dependent, c2 type; Helicase, C-terminal; SPTR: Putative uncharacterized protein [...]
    
 
 0.469
AEB11588.1
3-oxoacyl-(acyl-carrier-protein) synthase 2; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.
 
 
 0.464
AEB10837.1
Peptidyl-prolyl cis-trans isomerase cyclophilin type; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
   
 
 0.459
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.