STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB10885.1Protein of unknown function DUF6 transmembrane; InterPro IPR000620; KEGG: lhk:LHK_03120 hypothetical protein; PFAM: Drug/metabolite transporter; SPTR: Permeases of the drug/metabolite transporter (DMT) superfamily; IMG reference gene:2504659689; PFAM: EamA-like transporter family. (300 aa)    
Predicted Functional Partners:
AEB10882.1
Phospho-2-dehydro-3-deoxyheptonate aldolase; COGs: COG2876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase; InterProIPR010954:IPR006268:IPR002701:IPR020822:IPR 006218; KEGG: ttj:TTHA0388 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; PFAM: DAHP synthetase I/KDSA; Chorismate mutase, type II; SMART: Chorismate mutase; SPTR: Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; Chorismate mutase, Gram-positive bacteria/Deinococcus; IMG reference gene:2504659686; PFAM: Chorismate mutase type II; DAHP [...]
       0.782
AEB10884.1
methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
       0.780
AEB10883.1
InterPro IPR001450; KEGG: opr:Ocepr_2203 4fe-4S ferredoxin iron-sulfur binding domain protein; PFAM: 4Fe-4S binding domain; SPTR: 4Fe-4S ferredoxin iron-sulfur binding domain protein; IMG reference gene:2504659687.
       0.773
tatC
Sec-independent protein translocase, TatC subunit; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes.
  
  
 0.616
tatA
Sec-independent protein translocase protein tatA/E-like protein; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.
       0.608
AEB10886.1
Transcriptional regulator, HxlR family; COGs: COG1733 transcriptional regulator protein; InterPro IPR001845:IPR002577; KEGG: msv:Mesil_0609 transcriptional regulator, HxlR family; PFAM: Helix-turn-helix, HxlR type; SMART: HTH transcriptional regulator, ArsR; SPTR: Transcriptional regulator, HxlR family; IMG reference gene:2504659690; PFAM: HxlR-like helix-turn-helix.
  
    0.586
AEB10876.1
Protein of unknown function DUF456; COGs: COG2839 conserved hypothetical protein; InterPro IPR007403; KEGG: opr:Ocepr_2210 hypothetical protein; PFAM: Protein of unknown function DUF456; SPTR: Putative uncharacterized protein; IMG reference gene:2504659680; PFAM: Protein of unknown function (DUF456).
 
    0.535
glmU
Bifunctional protein glmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
       0.504
AEB10877.1
Glutaredoxin 2; InterPro IPR008554; KEGG: ttj:TTHA0383 putative thioredoxin; PFAM: Glutaredoxin-like; SPTR: Putative thioredoxin; IMG reference gene:2504659681; PFAM: Glutaredoxin-like domain (DUF836).
       0.428
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
       0.428
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.