STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB11039.1CRISPR-associated protein Cas4; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (192 aa)    
Predicted Functional Partners:
cas1
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 0.997
cas2-2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 
 0.983
AEB11036.1
CRISPR-associated protein Cas5 family; InterPro IPR013422:IPR010155:IPR021124; KEGG: sth:STH310 hypothetical protein; PFAM: CRISPR-associated protein, Cas5; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated protein, Cas5d-type; CRISPR-associated protein Cas5, N-terminal domain; IMG reference gene:2504659847; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, subtype I-C/DVULG; CRISPR-associated protein Cas5, N-terminal domain.
 
   
 0.955
AEB11038.1
CRISPR-associated protein, Csd2 family; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR006482:IPR013418; KEGG: mta:Moth_0495 CRISPR-associated Csh2 family protein; PFAM: CRISPR-associated protein TM1801; SPTR: CRISPR-associated protein TM1801; TIGRFAM: CRISPR-associated protein Csd2; CRISPR-associated protein TM1801; IMG reference gene:2504659849; PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein Cas7/Csd2, subtype I-C/DVULG.
 
   
 0.955
AEB11037.1
InterPro IPR010144; KEGG: slp:Slip_1546 CRISPR-associated protein, Csd1 family; PFAM: CRISPR-associated protein, Csd1-type; SPTR: CRISPR-associated protein, Csd1 family; TIGRFAM: CRISPR-associated protein, Csd1-type; IMG reference gene:2504659848; PFAM: CRISPR-associated protein (Cas_Csd1); TIGRFAM: CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG.
 
     0.954
AEB11035.1
Metal dependent phosphohydrolase; COGs: COG1203 helicase; InterPro IPR006483:IPR006474:IPR003607:IPR014001; KEGG: tth:TT_P0132 hypothetical protein; SMART: DEAD-like helicase, N-terminal; Metal-dependent phosphohydrolase, HD domain; SPTR: Hypothetical conserved protein; TIGRFAM: CRISPR-associated HD domain; Helicase Cas3, CRISPR-associated, core; IMG reference gene:2504659846; PFAM: DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated endonuclease Cas3-HD.
 
  
 0.948
cas2
CRISPR-associated protein Cas2; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 
 
 0.895
AEB12793.1
Metal dependent phosphohydrolase; COGs: COG1203 helicase; InterPro IPR003607:IPR014001:IPR006483; KEGG: rxy:Rxyl_0267 CRISPR-associated helicase Cas3 family protein protein; SMART: DEAD-like helicase, N-terminal; Metal-dependent phosphohydrolase, HD domain; SPTR: CRISPR-associated helicase Cas3; TIGRFAM: CRISPR-associated HD domain; IMG reference gene:2504661687; PFAM: DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated endonuclease Cas3-HD.
 
  
 0.766
AEB12792.1
CRISPR-associated protein, Csh2 family; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR013419:IPR006482; KEGG: rxy:Rxyl_0269 CRISPR-associated Csh2 family protein; PFAM: CRISPR-associated protein TM1801; SPTR: CRISPR-associated protein, Csh2 family; TIGRFAM: CRISPR-associated protein Csh2; CRISPR-associated protein TM1801; IMG reference gene:2504661685; PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein Cas7/Csh2, subtype I-B/HMARI.
 
   
 0.700
cas1-3
CRISPR-associated protein Cas1; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
  
 
 0.681
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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