STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa)    
Predicted Functional Partners:
tgt
Queuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...]
 
 0.993
AEB11646.1
Domain of unknown function DUF1730; COGs: COG1600 Uncharacterized Fe-S protein; InterPro IPR013542:IPR001450; KEGG: mrb:Mrub_1139 domain of unknown function DUF1730; PFAM: Domain of unknown function DUF1730; 4Fe-4S binding domain; SPTR: Putative uncharacterized protein; IMG reference gene:2504660489; PFAM: Domain of unknown function (DUF1730); TIGRFAM: iron-sulfur cluster binding protein, putative.
 
  
 0.806
ruvB
Holliday junction ATP-dependent DNA helicase ruvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.
  
  
 0.793
trmFO
Methylenetetrahydrofolate--tRNA-(uracil-5-)- methyltransferase trmFO; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily.
 
  
 0.792
AEB11633.1
Domain of unknown function DUF88; COGs: COG1432 conserved hypothetical protein; InterPro IPR021139; KEGG: opr:Ocepr_0830 hypothetical protein; PFAM: Domain of unknown function DUF88; SPTR: Putative uncharacterized protein; IMG reference gene:2504660476; PFAM: Protein of unknown function DUF88.
       0.764
AEB11632.1
Metallophosphoesterase; COGs: COG1409 phosphohydrolase; InterPro IPR004843; KEGG: opr:Ocepr_0829 metallophosphoesterase; PFAM: Metallo-dependent phosphatase; SPTR: Metallophosphoesterase; IMG reference gene:2504660475; PFAM: Calcineurin-like phosphoesterase.
       0.718
ruvA
Holliday junction ATP-dependent DNA helicase ruvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.
  
  
 0.648
AEB11630.1
Metallophosphoesterase; COGs: COG1692 conserved hypothetical protein; InterPro IPR004843; KEGG: ttj:TTHA0625 hypothetical protein; PFAM: Metallo-dependent phosphatase; SPTR: Putative uncharacterized protein TTHA0625; IMG reference gene:2504660473; TIGRFAM: metallophosphoesterase, MG_246/BB_0505 family.
       0.641
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.
       0.630
AEB11629.1
Protein of unknown function DUF255; COGs: COG1331 Highly conserved protein containing a thioredoxin domain; InterPro IPR004879:IPR010819; KEGG: msv:Mesil_1723 protein of unknown function DUF255; SPTR: Putative uncharacterized protein; IMG reference gene:2504660472; PFAM: Protein of unknown function, DUF255.
       0.610
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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