STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AEB11646.1Domain of unknown function DUF1730; COGs: COG1600 Uncharacterized Fe-S protein; InterPro IPR013542:IPR001450; KEGG: mrb:Mrub_1139 domain of unknown function DUF1730; PFAM: Domain of unknown function DUF1730; 4Fe-4S binding domain; SPTR: Putative uncharacterized protein; IMG reference gene:2504660489; PFAM: Domain of unknown function (DUF1730); TIGRFAM: iron-sulfur cluster binding protein, putative. (365 aa)    
Predicted Functional Partners:
AEB10884.1
methylated-DNA/protein- cysteinemethyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.
      0.904
queA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
  
 0.806
hflX
GTP-binding proten HflX; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.
       0.616
AEB11645.1
COGs: COG0760 Parvulin-like peptidyl-prolyl isomerase; InterPro IPR015391:IPR000297; KEGG: opr:Ocepr_0841 ppic-type peptidyl-prolyl cis-trans isomerase; PFAM: Peptidyl-prolyl cis-trans isomerase, PpiC-type; SurA N-terminal; SPTR: PpiC-type peptidyl-prolyl cis-trans isomerase; IMG reference gene:2504660488; PFAM: SurA N-terminal domain; PPIC-type PPIASE domain.
       0.603
AEB11643.1
HAD-superfamily hydrolase, subfamily IA, variant 3; COGs: COG0546 phosphatase; InterPro IPR006402:IPR006439:IPR005834; KEGG: msv:Mesil_2259 HAD-superfamily hydrolase, subfamily IA, variant 3; PFAM: Haloacid dehalogenase-like hydrolase; SPTR: HAD-superfamily hydrolase, subfamily IA, variant 3; TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; IMG reference gene:2504660486; PFAM: haloacid dehalogenase-like hydrolase; TIGRFAM: haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; haloacid [...]
     
 0.491
tadA
tRNA(Ile)-lysidine synthase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
  
 0.483
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
   
 0.471
queF
7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.
 
   
 0.469
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
   
 0.449
AEB11642.1
Protein of unknown function DUF218; COGs: COG1434 conserved hypothetical protein; InterPro IPR003848; KEGG: msv:Mesil_2261 protein of unknown function DUF218; PFAM: Domain of unknown function DUF218; SPTR: Putative uncharacterized protein; IMG reference gene:2504660485; PFAM: DUF218 domain.
       0.425
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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