Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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AEB11811.12-methylcitrate synthase/citrate synthase II; COGs: COG0372 Citrate synthase; InterPro IPR011278:IPR002020; KEGG: opr:Ocepr_0974 citrate synthase; PFAM: Citrate synthase-like; PRIAM: Citrate (Si)-synthase; SPTR: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase type I; IMG reference gene:2504660660; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family. (379 aa)    
Predicted Functional Partners:
AEB11800.1
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.999
AEB10926.1
2-methylcitrate dehydratase; COGs: COG2079 Uncharacterized protein involved in propionate catabolism; InterPro IPR005656; KEGG: vdi:Vdis_1889 2-methylcitrate dehydratase; PFAM: MmgE/PrpD; PRIAM: 2-methylcitrate dehydratase; SPTR: 2-methylcitrate dehydratase; IMG reference gene:2504659733; PFAM: MmgE/PrpD family.
 
 0.993
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.991
fumC
Fumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.977
AEB10925.1
Methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.
 
 0.975
AEB11368.1
Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.973
AEB11458.1
Dihydrolipoyllysine-residue acetyltransferase; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: msv:Mesil_1134 catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenase acyltransferase, catalytic domain; Biotin/lipoyl attachment; E3 binding; PRIAM: Dihydrolipoyllysine-residue acetyltransferase; SPTR: Catalytic domain of components of various dehydrogenase complexes; IMG reference gene:2504660296; PFAM: 2-oxoacid dehydrogenases acyltransferase (c [...]
  
 0.973
AEB12173.1
Isocitrate dehydrogenase, NADP-dependent; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804:IPR004439; KEGG: opr:Ocepr_1260 isocitrate dehydrogenase (nadp); PFAM: Isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: Isocitrate dehydrogenase [NADP]; TIGRFAM: Isocitrate dehydrogenase NADP-dependent, prokaryotic; IMG reference gene:2504661040; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type.
 
 0.965
AEB11963.1
COGs: COG2225 Malate synthase; InterPro IPR006252:IPR001465; KEGG: rmr:Rmar_2163 malate synthase A; PFAM: Malate synthase; PRIAM: Malate synthase; SPTR: Malate synthase; TIGRFAM: Malate synthase A; IMG reference gene:2504660817; PFAM: Malate synthase; TIGRFAM: malate synthase A; Belongs to the malate synthase family.
   
 0.961
AEB12549.1
Transcriptional regulator, IclR family; COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR005471:IPR014757:IPR000873; KEGG: mrb:Mrub_1301 transcriptional regulator, IclR family; PFAM: AMP-dependent synthetase/ligase; Transcription regulator IclR, C-terminal; Transcription regulator IclR, N-terminal; PRIAM: Acetate--CoA ligase; SPTR: Transcriptional regulator, IclR family; IMG reference gene:2504661430; PFAM: Domain of unknown function (DUF3448); IclR helix-turn-helix domain; Bacterial transcriptional regulator; AMP-binding enzyme.
  
 0.961
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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