STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
AEB11844.1Diguanylate cyclase with GAF sensor; COGs: COG2199 FOG: GGDEF domain; InterPro IPR003018:IPR000160; KEGG: opr:Ocepr_1009 diguanylate cyclase with gaf sensor; PFAM: Diguanylate cyclase, predicted; GAF; SMART: Diguanylate cyclase, predicted; GAF; SPTR: GGDEF domain protein; TIGRFAM: Diguanylate cyclase, predicted; IMG reference gene:2504660693; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. (629 aa)    
Predicted Functional Partners:
AEB12027.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR013655:IPR013767:IPR003018:IPR000160:IPR 001633:IPR000014:IPR001610; KEGG: aae:aq_1442 hypothetical protein; PFAM: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; GAF; PAS fold-3; PAS fold; SMART: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; GAF; PAS; PAC motif; SPTR: Putative uncharacterized protein; TIGRFAM: PAS; Diguanylate cyclase, predicted; IMG ref [...]
 
 
 0.964
AEB10784.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterProIPR000014:IPR000160:IPR001610:IPR003018:IPR 001633:IPR013656:IPR013767; KEGG: opr:Ocepr_0163 diguanylate cyclase/phosphodiesterase with pas/pac and gaf sensor(s); PFAM: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; PAS fold; GAF; PAS fold-4; SMART: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; GAF; PAS; PAC motif; SPTR: Diguanylate cyclase/phosphodiesteras [...]
 
 
0.925
AEB11357.1
Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s); COGs: COG2200 FOG: EAL domain; InterProIPR013767:IPR000160:IPR001633:IPR000014:IPR 001610; KEGG: mrb:Mrub_2168 diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(s); PFAM: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; PAS fold; SMART: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; PAS; PAC motif; SPTR: Diguanylate cyclase/phosphodiesterase with PAS/PAC and GAF sensor(S); TIGRFAM: Diguanylate cyclase, predicted; PAS; IMG reference gene:2504660194; PFAM: E [...]
 
 
0.887
AEB11796.1
Metal dependent phosphohydrolase with GAF sensor; COGs: COG2206 HD-GYP domain; InterPro IPR003018:IPR003607:IPR006675:IPR006674; KEGG: opr:Ocepr_0904 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; GAF; SMART: Metal-dependent phosphohydrolase, HD domain; GAF; SPTR: Metal dependent phosphohydrolase; TIGRFAM: Uncharacterised protein family HDIG; IMG reference gene:2504660645; PFAM: HD domain; GAF domain; TIGRFAM: uncharacterized domain HDIG.
 
 0.887
AEB10895.1
Metal dependent phosphohydrolase; COGs: COG2206 HD-GYP domain; InterPro IPR003607:IPR006674; KEGG: msv:Mesil_1339 metal dependent phosphohydrolase; PFAM: Metal-dependent phosphohydrolase, HD subdomain; SMART: Metal-dependent phosphohydrolase, HD domain; SPTR: Metal dependent phosphohydrolase; IMG reference gene:2504659701; PFAM: HD domain.
 
 0.865
AEB12537.1
Diguanylate cyclase/phosphodiesterase with GAF sensor; COGs: COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain; InterPro IPR003018:IPR000160:IPR001633; KEGG: mau:Micau_6257 diguanylate cyclase; PFAM: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; GAF; SMART: Diguanylate phosphodiesterase, EAL domain; Diguanylate cyclase, predicted; GAF; SPTR: Diguanylate cyclase; TIGRFAM: Diguanylate cyclase, predicted; IMG reference gene:2504661416; PFAM: EAL domain; GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
 
0.728
AEB11636.1
COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054:IPR011717; KEGG: opr:Ocepr_0833 adenylate/guanylate cyclase; PFAM: Adenylyl cyclase class-3/4/guanylyl cyclase; Tetratricopeptide TPR-4; SMART: Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Putative adenylate/guanylate cyclase; IMG reference gene:2504660479; PFAM: Adenylate and Guanylate cyclase catalytic domain.
 
  
 0.630
AEB11587.1
KEGG: msv:Mesil_1375 hypothetical protein; SPTR: Putative uncharacterized protein; IMG reference gene:2504660429; PFAM: Protein of unknown function (DUF3467).
   
 
 0.582
AEB12127.1
Transcriptional regulator, BadM/Rrf2 family; COGs: COG1959 transcriptional regulator protein; InterPro IPR000944; KEGG: msv:Mesil_1591 transcriptional regulator, BadM/Rrf2 family; PFAM: Transcription regulator Rrf2; SPTR: Transcriptional regulator, BadM/Rrf2 family; TIGRFAM: Transcription regulator Rrf2; IMG reference gene:2504660991; PFAM: Transcriptional regulator; TIGRFAM: Rrf2 family protein.
 
   
 0.552
AEB12023.1
COGs: COG0069 Glutamate synthase domain 2; InterPro IPR000583:IPR006982:IPR002932:IPR002489; KEGG: tra:Trad_0209 glutamate synthase; PFAM: Glutamate synthase, central-C; Glutamine amidotransferase, class-II; Glutamate synthase, central-N; Glutamate synthase, alpha subunit, C-terminal; PRIAM: Glutamate synthase (ferredoxin); SPTR: Glutamate synthase (Ferredoxin); IMG reference gene:2504660877; PFAM: Conserved region in glutamate synthase; GXGXG motif; Glutamate synthase central domain; Glutamine amidotransferases class-II.
     
 0.546
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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