STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tdkCOGs: COG1435 Thymidine kinase; HAMAP: Thymidine kinase, subgroup; InterPro IPR001267:IPR020634; KEGG: msv:Mesil_2208 thymidine kinase; PFAM: Thymidine kinase; PRIAM: Thymidine kinase; SPTR: Thymidine kinase; IMG reference gene:2504660997; PFAM: Thymidine kinase. (201 aa)    
Predicted Functional Partners:
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.939
AEB10999.1
COGs: COG0213 Thymidine phosphorylase; InterPro IPR018090:IPR013102:IPR017459:IPR000312; KEGG: opr:Ocepr_0456 thymidine phosphorylase; PFAM: Glycosyl transferase, family 3; Glycosyl transferase, family 3, N-terminal; Pyrimidine nucleoside phosphorylase, C-terminal; PRIAM: Pyrimidine-nucleoside phosphorylase; SMART: Pyrimidine nucleoside phosphorylase, C-terminal; SPTR: Thymidine phosphorylase; TIGRFAM: Pyrimidine-nucleoside phosphorylase, bacterial/eukaryotic; IMG reference gene:2504659809; PFAM: Pyrimidine nucleoside phosphorylase C-terminal domain; Glycosyl transferase family, a/b do [...]
    
 0.930
AEB11668.1
COGs: COG0813 Purine-nucleoside phosphorylase; InterPro IPR000845; KEGG: opr:Ocepr_0785 purine-nucleoside phosphorylase; PFAM: Nucleoside phosphorylase domain; PRIAM: Purine-nucleoside phosphorylase; SPTR: Purine or other phosphorylase family 1; IMG reference gene:2504660511; PFAM: Phosphorylase superfamily; TIGRFAM: purine-nucleoside phosphorylase, family 1 (deoD).
  
 
 0.923
AEB11866.1
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family.
    
 0.923
surE
Multifunctional protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
  
  
  0.918
thyX
Thymidylate synthase thyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.
    
 0.918
AEB11639.1
Purine nucleoside phosphorylase I, inosine and guanosine-specific; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.
    
  0.907
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
  
  
 0.842
rpmE
50S ribosomal protein L31; Binds the 23S rRNA.
     
 0.644
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
  
  
 0.634
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.