STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pyrBCOGs: COG0540 Aspartate carbamoyltransferase catalytic chain; HAMAP: Aspartate carbamoyltransferase, eukaryotic; InterPro IPR006132:IPR006131:IPR002082; KEGG: msv:Mesil_1878 aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding; Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain; PRIAM: Aspartate carbamoyltransferase; SPTR: Aspartate carbamoyltransferase; TIGRFAM: Aspartate carbamoyltransferase, eukaryotic; IMG reference gene:2504661002; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/orni [...] (305 aa)    
Predicted Functional Partners:
carA
COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006274:IPR002474:IPR000991; KEGG: ttj:TTHA0280 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase, small subunit, N-terminal; Glutamine amidotransferase class-I, C-terminal; PRIAM: Carbamoyl-phosphate synthase (glutamine-hydrolyzing); SPTR: Carbamoyl-phosphate synthase small chain; TIGRFAM: Carbamoyl-phosphate synthase, small subunit; IMG reference gene:2504660367; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate [...]
 
 0.999
pyrR
Bifunctional protein pyrR; Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.
 
 0.999
pyrC
Dihydroorotase, multifunctional complex type; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
 0.999
carB
COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005481:IPR005479:IPR005480:IPR006275; KEGG: mrb:Mrub_0916 carbamoyl-phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthetase, large subunit, ATP-binding; Carbamoyl-phosphate synthase, large subunit, N-terminal; Carbamoyl-phosphate synthetase, large subunit, oligomerisation; PRIAM: Carbamoyl-phosphate synthase (ammonia); SPTR: Carbamoyl-phosphate synthase large chain; TIGRFAM: Carbamoyl-phosphate synthase, large subunit; IMG reference gene:2504661118; PFAM: Carbamoyl-phosphate synthase [...]
 
 0.999
pyrD
Dihydroorotate dehydrogenase family protein; Catalyzes the conversion of dihydroorotate to orotate.
 
  
 0.992
AEB12140.1
COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR001433:IPR019480; KEGG: opr:Ocepr_0965 dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain; PFAM: Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain; Oxidoreductase FAD/NAD(P)-binding; SPTR: Oxidoreductase FAD/NAD(P)-binding domain protein; IMG reference gene:2504661004; PFAM: Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B; Oxidoreductase NAD-binding domain.
  
  
 0.987
AEB12513.1
COGs: COG2233 Xanthine/uracil permease; InterPro IPR006043:IPR006042; KEGG: opr:Ocepr_1542 uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; SPTR: Uracil-xanthine permease; TIGRFAM: Xanthine/uracil permease; IMG reference gene:2504661390; PFAM: Permease family; TIGRFAM: uracil-xanthine permease.
  
  
 0.963
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
  
 0.963
pyrF
COGs: COG0284 Orotidine-5'-phosphate decarboxylase; HAMAP: Orotidine 5'-phosphate decarboxylase, type 2; InterPro IPR011995:IPR001754; KEGG: msv:Mesil_2713 orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase domain; PRIAM: Orotidine-5'-phosphate decarboxylase; SMART: Orotidine 5'-phosphate decarboxylase domain; SPTR: Orotidine 5'-phosphate decarboxylase; TIGRFAM: Orotidine 5'-phosphate decarboxylase, type 2; IMG reference gene:2504661518; PFAM: Orotidine 5'-phosphate decarboxylase / HUMPS family; TIGRFAM: orotidine 5'-phosphate decarboxylase, subfamily 2; B [...]
  
  
 0.963
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.935
Your Current Organism:
Marinithermus hydrothermalis
NCBI taxonomy Id: 869210
Other names: M. hydrothermalis DSM 14884, Marinithermus hydrothermalis DSM 14884, Marinithermus hydrothermalis T1, Marinithermus hydrothermalis str. DSM 14884, Marinithermus hydrothermalis strain DSM 14884
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